The relationship between methylenetetrahydrofolate reductase c.677TT genotype and oligozoospermia in infertile male patients living in the Trakya region of Turkey

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dc.authoridGürkan, Hakan/0000-0002-8967-6124
dc.authoridYazar, Metin/0000-0002-2657-3072
dc.authoridDemir, Selma/0000-0002-0964-5513
dc.authorwosidGürkan, Hakan/AAF-2866-2020
dc.authorwosidYazar, Metin/ABA-3934-2020
dc.authorwosidDemir, Selma/A-1500-2018
dc.contributor.authorGurkan, H.
dc.contributor.authorTozkir, H.
dc.contributor.authorGoncu, E.
dc.contributor.authorUlusal, S.
dc.contributor.authorYazar, M.
dc.date.accessioned2024-06-12T10:54:08Z
dc.date.available2024-06-12T10:54:08Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMethylenetetrahydrofolate reductase (MTHFR), the key enzyme of the folate metabolic pathway, has been reported to be five times more active in the testicles compared to other organs in adult mice. The aim of this study was to investigate the relationship between MTHFR c.677C>T and c.1298A>C polymorphisms and infertility in nonobstructive azoospermic and oligozoospermic male patients living in the Trakya region of Turkey. The study population included 75 nonobstructive azoospermic and 62 oligozoospermic, nonconsanguineous patients who were referred to the Department of Medical Genetics of Trakya University between 01.03.2012 and 01.06.2013 due to infertility and who had been diagnosed based on clinical examinations and spermiograms. All of the patients had a normal karyotype without a Y chromosome microdeletion. Melting curve analysis with labelled probes and primers that were designed by the manufacturers and the real-time polymerase chain reaction method were used. The MTHFR c.677TT genotype frequency in the oligozoospermic infertile male patient group was greater than that of the fertile control group [odds ratio (OR)=2.675 (95% CI: 0.979-7.305), (P<0.048)]. The MTHFR c.677TT genotype may be a genetic risk factor for oligozoospermic infertile male patients who live in the Trakya region of Turkey.en_US
dc.identifier.doi10.1111/and.12380
dc.identifier.endpage1074en_US
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue9en_US
dc.identifier.pmid25428700en_US
dc.identifier.scopus2-s2.0-84970924770en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1068en_US
dc.identifier.urihttps://doi.org/10.1111/and.12380
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18938
dc.identifier.volume47en_US
dc.identifier.wosWOS:000362446400015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAzoospermiaen_US
dc.subjectMale Infertilityen_US
dc.subjectMTHFRen_US
dc.subjectOligozoospermiaen_US
dc.subjectMthfr C677t Polymorphismen_US
dc.subjectGenetic Polymorphismsen_US
dc.subjectA1298c Polymorphismen_US
dc.subjectY-Chromosomeen_US
dc.subjectRisken_US
dc.subjectAzoospermiaen_US
dc.subjectMutationen_US
dc.titleThe relationship between methylenetetrahydrofolate reductase c.677TT genotype and oligozoospermia in infertile male patients living in the Trakya region of Turkeyen_US
dc.typeArticleen_US

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