Melatonin attenuates oxidative stress, liver damage and hepatocyte apoptosis after bile-duct ligation in rats

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dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorAktas, Cevat
dc.contributor.authorKanter, Mehmet
dc.contributor.authorErboga, Mustafa
dc.contributor.authorMete, Rafet
dc.contributor.authorOran, Mustafa
dc.date.accessioned2024-06-12T10:54:30Z
dc.date.available2024-06-12T10:54:30Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe goal of this study was to evaluate the possible protective effects of melatonin against cholestatic oxidative stress, liver damage and hepatocyte apoptosis in the common rats with bile duct ligation (BDL). A total of 24 male Wistar albino rats were divided into three groups: control, BDL and BDL + received melatonin; each group contains eight animals. Melatonin-treated BDL rats received daily melatonin 100 mg/kg/day via intraperitoneal injection. The application of BDL clearly increased the malondialdehyde (MDA) levels and decreased the superoxide dismutase (SOD) and glutathione (GSH) activities. Melatonin treatment significantly decreased the elevated tissue MDA levels and increased the reduced SOD and GSH enzyme levels in the tissues. The changes demonstrate that the bile duct proliferation and fibrosis in expanded portal tracts include the extension of proliferated bile ducts into lobules, mononuclear cells and neutrophil infiltration into the widened portal areas as observed in the BDL group. The data indicate that melatonin attenuates BDL-induced cholestatic liver injury, bile duct proliferation and fibrosis. The alpha-smooth muscle actin (alpha-SMA) and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells in the BDL were observed to be reduced with the melatonin treatment. These results suggest that administration of melatonin is a potentially beneficial agent to reduce liver damage in BDL by decreasing oxidative stress.en_US
dc.identifier.doi10.1177/0748233712464811
dc.identifier.endpage844en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue9en_US
dc.identifier.pmid23095487en_US
dc.identifier.scopus2-s2.0-84910035016en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage835en_US
dc.identifier.urihttps://doi.org/10.1177/0748233712464811
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19077
dc.identifier.volume30en_US
dc.identifier.wosWOS:000342991800007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology And Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBile Duct Ligationen_US
dc.subjectLiveren_US
dc.subjectMelatoninen_US
dc.subjectOxidative Stressen_US
dc.subjectApoptosisen_US
dc.subjectAlpha-Smaen_US
dc.subjectBiliary-Obstructed Ratsen_US
dc.subjectHepatic Stellate Cellsen_US
dc.subjectCarbon-Tetrachlorideen_US
dc.subjectFibrosisen_US
dc.subjectPathogenesisen_US
dc.subjectExpressionen_US
dc.subjectJaundiceen_US
dc.subjectInjuryen_US
dc.subjectInhibitionen_US
dc.subjectActivationen_US
dc.titleMelatonin attenuates oxidative stress, liver damage and hepatocyte apoptosis after bile-duct ligation in ratsen_US
dc.typeArticleen_US

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