Radyokontrast maddeye bağlı gelişen akut böbrek hasarında karnosik asid'in koruyucu etkinliğinin araştırılması
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Dosyalar
Tarih
2020
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Yayıncı
Trakya Üniversitesi, Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
CIN hastane ilişkili akut renal yetmezliğin üçüncü en sık sebebini oluşturur ve akut renal yetmezlik vakalar içinde yaklaşık % 10 insidansa sahiptir. Kontrast madde kaynaklı nefropati; özellikle işlem öncesi kronik böbrek hasarı bulunan bireylerde daha fazla olmak üzere birçok risk faktörü ile birlikte görülebilen ve mortalite ve morbiditede ciddi artışa yol açan klinik bir antitedir. Kontrast madde nefropatisi için risk arzeden gruplardan biri de özellikle nefropati gelişmiş olanlar olmak üzere diabetik hasta grubudur. Diabetik nefropatide iyileştirici etkileri saptanan Karnosik asidin kontrast madde nefropatisinde tedavi edici etkisi olup olmadığını araştırmayı amaçladık. 24 ratın kullanıldığı deneyde 8 er denekten oluşan biri kontrol, diğerleri model ve tedavi grupları olmak üzere 3 ayrı grup oluşturuldu. Model ve tedavi grubundaki deneklerde 48 saatlik dehidratasyondan sonra 10 ml/kg intramuskuler Furosemid ve 10 ml/kg intravenöz Ioheksol kullanılarak nefropati geliştirildi. Tedavi grubuna 1 ve 5. günler arasında 5 gün süreyle Karnosik asid 30 mg/kg/gün dozunda orogastrik kateter vasıtasıyla verildi. Çalışma sonucunda Karnosik asitle tedavi edilen grupta Üre, Sodyum ve Kreatin kinaz düzeylerinde istatistiksel anlamlı farklılık saptandı. Histopatolojik incelemede de tedavi grubunda iyileştirici etki gözlendi ancak istatistiksel değerlendirmeye yetecek sayıda örneklem olmadığından bu yönde bir hesaplama yapılamadı. Bu bulgular neticesinde özellikle tedavi süresi ve doz üzerinde yapılacak değişikliklerle optimal etkinin sağlanacağı değerlerin bulunmasıyla Karnosik asidin CIN tedavisinde kullanılabileceği kanaatindeyiz. Bu doğrultuda yeni çalışmalara ihtiyaç vardır.
CIN is the third most common cause of hospital-related acute renal failure, and acute renal failure has an incidence of about 10% in cases of insufficiency. Contrast-media nephropathy is a clinical entity that leads to serious increase on mortality and morbidity which can be present with several risc factors, especially in individuals with chronic kidney damage before the procedure. One of the risk groups for contrast material nephropathy is diabetic patients, especially those with nephropathy. We aimed to investigate whether carnosic acid has a therapeutic effect on contrast media nephropathy, which has curative effect in diabetic nephropathy. In the experiment using 24 rats, one of the 8 subjects was used as a control and the other groups were formed as a model ( 8 rats ) and treatment groups (8 rats). Nephropathy was developed using intramuscular Furosemide (10 ml/ kg) and intravenous Iohexol (10 ml/ kg) after 48 hours of dehydration in the model and treatment groups. Carnosic acid was given to the treatment group between the 1st and 5th days for 5 days via using an orogastric catheter at 30 mg/ kg/ day. Urea, sodium and creatine kinase levels were found statistically significant in carnosic acid treated group. Histopathological examination also showed improvement effect in the treatment group but sample size was not enough for statistical evaluation. As a result of these findings, especially on the duration of treatment and dose, values for optimal effect of carnosic acid can be found and we believe that it can be used in the treatment of CIN. In this respect, new studies are needed.
CIN is the third most common cause of hospital-related acute renal failure, and acute renal failure has an incidence of about 10% in cases of insufficiency. Contrast-media nephropathy is a clinical entity that leads to serious increase on mortality and morbidity which can be present with several risc factors, especially in individuals with chronic kidney damage before the procedure. One of the risk groups for contrast material nephropathy is diabetic patients, especially those with nephropathy. We aimed to investigate whether carnosic acid has a therapeutic effect on contrast media nephropathy, which has curative effect in diabetic nephropathy. In the experiment using 24 rats, one of the 8 subjects was used as a control and the other groups were formed as a model ( 8 rats ) and treatment groups (8 rats). Nephropathy was developed using intramuscular Furosemide (10 ml/ kg) and intravenous Iohexol (10 ml/ kg) after 48 hours of dehydration in the model and treatment groups. Carnosic acid was given to the treatment group between the 1st and 5th days for 5 days via using an orogastric catheter at 30 mg/ kg/ day. Urea, sodium and creatine kinase levels were found statistically significant in carnosic acid treated group. Histopathological examination also showed improvement effect in the treatment group but sample size was not enough for statistical evaluation. As a result of these findings, especially on the duration of treatment and dose, values for optimal effect of carnosic acid can be found and we believe that it can be used in the treatment of CIN. In this respect, new studies are needed.
Açıklama
Anahtar Kelimeler
Kontrast Madde, Kontrast Madde Nefropatisi, Karnosik Asid, Contrast Media, Contrast Induced Nephropathy, Carnosic Acid
