Effect of Activation of the GLT-1 Transporter by a Beta-Lactam Antibiotic on Serotonin-Induced Scratching Behavior in Mice

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dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridtodurga seven, zeynep gizem/0000-0002-2529-0118
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidtodurga seven, zeynep gizem/AAB-7657-2020
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorGunduz, O.
dc.contributor.authorTopuz, R. D.
dc.contributor.authorTodurga, Z. G.
dc.contributor.authorDuvan, K.
dc.contributor.authorKaradag, C. H.
dc.contributor.authorUlugol, A.
dc.date.accessioned2024-06-12T10:55:59Z
dc.date.available2024-06-12T10:55:59Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractGlutamate is believed to be the predominant excitatory neurotransmitter in the networks responsible for itch-related behavior. Beta-lactam antibiotics were shown to exert neuroprotective effects by increasing expression of the glutamate transporter GLT-1. We observed whether repeated administration of the beta-lactam antibiotic ceftriaxone suppresses serotonin-induced itch-related behavior (similarly to the effect of this agent on pain transmission) in mice. Chronic, but not acute, ceftriaxone introductions reduced the number of serotonin-induced scratches; dihydrokainic acid, a selective GLT-1 transporter inhibitor, partly but significantly abolished this effect of ceftriaxone. Our findings suggest that GLT-1 activation by beta-lactam antibiotics looks promising for the treatment of chronic itch.en_US
dc.identifier.doi10.1007/s11062-015-9494-1
dc.identifier.endpage39en_US
dc.identifier.issn0090-2977
dc.identifier.issn1573-9007
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84953363041en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage36en_US
dc.identifier.urihttps://doi.org/10.1007/s11062-015-9494-1
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19627
dc.identifier.volume47en_US
dc.identifier.wosWOS:000354054500007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNeurophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCeftriaxoneen_US
dc.subjectGlutamate Transporter GLT-1en_US
dc.subjectItchen_US
dc.subjectSerotoninen_US
dc.subjectSpinal-Corden_US
dc.subjectItchen_US
dc.subjectPainen_US
dc.subjectNeurotransmitteren_US
dc.subjectTransmissionen_US
dc.subjectCeftriaxoneen_US
dc.subjectExpressionen_US
dc.subjectToleranceen_US
dc.subjectInsightsen_US
dc.subjectNeuronsen_US
dc.titleEffect of Activation of the GLT-1 Transporter by a Beta-Lactam Antibiotic on Serotonin-Induced Scratching Behavior in Miceen_US
dc.typeArticleen_US

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