Characteristics Predicting Tuberculosis Risk under Tumor Necrosis Factor-? Inhibitors: Report from a Large Multicenter Cohort with High Background Prevalence

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dc.authoridHatemi, Gulen/0000-0002-1952-1135
dc.authoridGul, Ahmet/0000-0001-8219-3720
dc.authoridYILMAZ, Sedat/0000-0002-4691-3417
dc.authoridYazıcı, Ayten/0000-0003-2167-4509
dc.authoridozguler, yesim/0000-0002-2082-4715
dc.authorwosidCan, Meryem/HLP-4890-2023
dc.authorwosidDireskeneli, Haner/AAS-5508-2020
dc.authorwosidHatemi, Gulen/AAC-9647-2021
dc.authorwosidErtenli, Ihsan/AAV-7175-2021
dc.authorwosidGul, Ahmet/AAT-7787-2020
dc.authorwosidpehlivan, yavuz/AAG-8227-2021
dc.authorwosidOzguler, Yesim/AAE-9565-2019
dc.contributor.authorKisacik, Bunyamin
dc.contributor.authorPamuk, Omer Nuri
dc.contributor.authorOnat, Ahmet Mesut
dc.contributor.authorErer, Sait Burak
dc.contributor.authorHatemi, Gulen
dc.contributor.authorOzguler, Yesim
dc.contributor.authorPehlivan, Yavuz
dc.date.accessioned2024-06-12T11:16:44Z
dc.date.available2024-06-12T11:16:44Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective. Screening strategies for latent tuberculosis (TB) before starting tumor necrosis factor (TNF)-alpha inhibitors have decreased the prevalence of TB among patients who are treated with these agents. However, despite vigilant screening, TB continues to be an important problem, especially in parts of the world with a high background TB prevalence. The aim of this study was to determine the factors related to TB among a large multicenter cohort of patients who were treated with anti-TNF. Methods. Fifteen rheumatology centers participated in this study. Among the 10,434 patients who were treated with anti-TNF between September 2002 and September 2012, 73 (0.69%) had developed TB. We described the demographic features and disease characteristics of these 73 patients and compared them to 7695 patients who were treated with anti-TNF, did not develop TB, and had complete data available. Results. Among the 73 patients diagnosed with TB (39 men, 34 women, mean age 43.6 +/- 13 yrs), the most frequent diagnoses were ankylosing spondylitis (n = 38) and rheumatoid arthritis (n = 25). More than half of the patients had extrapulmonary TB (39/73, 53%). Six patients died (8.2%). In the logistic regression model, types of anti-TNF drugs [infliximab (IFX), OR 3.4, 95% CI 1.88-6.10, p = 0.001] and insufficient and irregular isoniazid use (<9 mos; OR 3.15, 95% CI 1.43-6.9, p = 0.004) were independent predictors of TB development. Conclusion. Our results suggest that TB is an important complication of anti-TNF therapies in Turkey. TB chemoprophylaxis less than 9 months and the use of IFX therapy were independent risk factors for TB development.en_US
dc.identifier.doi10.3899/jrheum.150177
dc.identifier.endpage529en_US
dc.identifier.issn0315-162X
dc.identifier.issn1499-2752
dc.identifier.issue3en_US
dc.identifier.pmid26773107en_US
dc.identifier.scopus2-s2.0-84959906308en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage524en_US
dc.identifier.urihttps://doi.org/10.3899/jrheum.150177
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24431
dc.identifier.volume43en_US
dc.identifier.wosWOS:000378167600010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJ Rheumatol Publ Coen_US
dc.relation.ispartofJournal Of Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTUMOR NECROSIS FACTOR-A INHIBITORSen_US
dc.subjectTUBERCULOSIS REACTIVATIONen_US
dc.subjectISONIAZIDen_US
dc.subjectRheumatoid-Arthritisen_US
dc.subjectFactor Antagonistsen_US
dc.subjectTherapyen_US
dc.subjectTnfen_US
dc.subjectMortalityen_US
dc.subjectInfectionsen_US
dc.subjectTermen_US
dc.titleCharacteristics Predicting Tuberculosis Risk under Tumor Necrosis Factor-? Inhibitors: Report from a Large Multicenter Cohort with High Background Prevalenceen_US
dc.typeArticleen_US

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