Curcumin attenuates testicular damage, apoptotic germ cell death, and oxidative stress in streptozotocin-induced diabetic rats

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dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorKanter, Mehmet
dc.contributor.authorAktas, Cevat
dc.contributor.authorErboga, Mustafa
dc.date.accessioned2024-06-12T10:52:27Z
dc.date.available2024-06-12T10:52:27Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractScope: The present study was designed to examine the protective and antioxidative effects of curcumin (Cur) on streptozotocin (STZ) induced testicular damage, apoptotic germ cell death, and oxidative stress. Methods and resultsDiabetes was induced by a single intraperitoneal injection of STZ (50 mg/kg). The rats in the Cur-treated group were given Cur (100 mg/kg) once a day intragastrik for 8 weeks starting 3 days prior to STZ injection. Cur treatment significantly decreased the elevated tissue malondialdehyde levels and increased the reduced superoxide dismutase, and glutathione peroxidase enzyme activities in testis tissues samples. The Cur-treated rats in the diabetic group showed an improved histological appearance and serum testosterone levels. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end-labeling and there was a rise in the expression of proliferating cell nuclear antigen in testis tissues of Cur-treated rats in the diabetic group. ConclusionThese results demonstrate that Cur attenuated testicular damage in diabetic rats by decreasing oxidative stress.en_US
dc.identifier.doi10.1002/mnfr.201200170
dc.identifier.endpage1585en_US
dc.identifier.issn1613-4125
dc.identifier.issn1613-4133
dc.identifier.issue9en_US
dc.identifier.pmid22930655en_US
dc.identifier.scopus2-s2.0-84883376154en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1578en_US
dc.identifier.urihttps://doi.org/10.1002/mnfr.201200170
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18696
dc.identifier.volume57en_US
dc.identifier.wosWOS:000327666600008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofMolecular Nutrition & Food Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptozisen_US
dc.subjectCurcuminen_US
dc.subjectDiabetesen_US
dc.subjectOxidative Stressen_US
dc.subjectTestisen_US
dc.subjectFree-Radicalsen_US
dc.subjectSeminiferous Tubulesen_US
dc.subjectNuclear Antigenen_US
dc.subjectTestisen_US
dc.subjectInjuryen_US
dc.subjectMalondialdehydeen_US
dc.subjectAntioxidanten_US
dc.subjectPeroxidaseen_US
dc.subjectParametersen_US
dc.subjectQuercetinen_US
dc.titleCurcumin attenuates testicular damage, apoptotic germ cell death, and oxidative stress in streptozotocin-induced diabetic ratsen_US
dc.typeArticleen_US

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