Nucleated red blood cell counts and erythropoietin levels in high-risk neonates

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dc.contributor.authorVatansever, Ü
dc.contributor.authorAcuna, B
dc.contributor.authorDemir, M
dc.contributor.authorKarasalihoglu, S
dc.contributor.authorEkuklu, G
dc.contributor.authorEner, S
dc.contributor.authorPala, Ö
dc.date.accessioned2024-06-12T11:01:29Z
dc.date.available2024-06-12T11:01:29Z
dc.date.issued2002
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground : The presence of increased numbers of nucleated red blood cells (NRBC) and increased levels of erythropoietin (EPO) in the circulation of neonates has been associated with states of relative hypoxia. The aim of this study is to assess the pattern of NRBC counts and EPO levels in a group of high-risk neonates under stress conditions and determine the short-term outcome for these babies by using these parameters. Methods : There were 69 high-risk neonates; 14 intrauterine growth retarded ( IUGR), 25 preterm infants, 18 term infants with asphyxia and 12 infants of diabetic mothers. Control groups included healthy, term infants delivered either vaginally (n=18) or with cesarean section (n=19). Three blood samples were obtained from each infant within 12 h (initial), 3 days and 7 days after birth to measure NRBC counts and EPO levels. Neonatal and short-term outcomes at 3 and 6 months of age were determined. Results : There was no significant difference among the groups with regard to the initial serum EPO concentrations. The initial NRBC counts were significantly lower in the control groups compared with the study groups (P=0.002). While there was no significant difference between patients with good and poor outcome in terms of EPO concentrations of initial samples, a significant difference existed in terms of NRBC counts (P=0.038). Conclusions : Both serum EPO level and NRBC count provide limited clinical benefit in the detection of pathological conditions of the neonatal period, but NRBC count determination seems to be especially helpful in predicting short-term neurodevelopmental outcome.en_US
dc.identifier.doi10.1046/j.1442-200X.2002.01630.x
dc.identifier.endpage595en_US
dc.identifier.issn1328-8067
dc.identifier.issue6en_US
dc.identifier.pmid12421253en_US
dc.identifier.scopus2-s2.0-0036434425en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage590en_US
dc.identifier.urihttps://doi.org/10.1046/j.1442-200X.2002.01630.x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20900
dc.identifier.volume44en_US
dc.identifier.wosWOS:000179043300002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishing Asiaen_US
dc.relation.ispartofPediatrics Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectErythropoietinen_US
dc.subjectNucleated Red Blood Cellen_US
dc.subjectHigh-Risk Neonateen_US
dc.subjectHypoxiaen_US
dc.subjectShort-Term Outcomeen_US
dc.subjectSerum-Immunoreactive Erythropoietinen_US
dc.subjectGestational-Age Fetusesen_US
dc.subjectPerinatal Brain-Damageen_US
dc.subjectFetal Distressen_US
dc.subjectHypoxiaen_US
dc.subjectSeizuresen_US
dc.subjectAsphyxiaen_US
dc.subjectInjuryen_US
dc.subjectMarkeren_US
dc.subjectIndexen_US
dc.titleNucleated red blood cell counts and erythropoietin levels in high-risk neonatesen_US
dc.typeArticleen_US

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