Investigation of VEGF and IL-8 Gene Polymorphisms in Patients with Differentiated Thyroid Cancer

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dc.authoridÇelik, Özlem/0000-0001-5149-8716
dc.authoridPalabıyık, Orkide/0000-0002-3488-3740;
dc.authorwosidÇelik, Özlem/HPC-2361-2023
dc.authorwosidCELIK, OZLEM/A-5240-2018
dc.authorwosidPalabıyık, Orkide/Q-2792-2019
dc.authorwosidÇelik, Özlem/AAA-1326-2022
dc.contributor.authorKilic, Ilhan
dc.contributor.authorGuldiken, Sibel
dc.contributor.authorSipahi, Tammam
dc.contributor.authorPalabiyik, Orkide
dc.contributor.authorAkker, Mustafa
dc.contributor.authorCelik, Ozlem
dc.contributor.authorSoysal-Atile, Neslihan
dc.date.accessioned2024-06-12T10:59:37Z
dc.date.available2024-06-12T10:59:37Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Differentiated thyroid carcinomas (DTC) account for most of the thyroid cancers. The emergence of DTC may be affected by various predisposing genetic alterations and environmental factors The aim of this study was to investigate the role of VEGF C936T and IL-8 A251T gene polymorphisms in the pathogenesis and metastasis of differentiated thyroid cancer. Methods: The study consisted of 101 patients DTC patients and 109 healthy controls. The parameters of the stage of cancer of the DTC patients at the time of diagnosis (TNM) were recorded. DNA was isolated from blood using a DNA isolation kit. VEGF C936T and IL-8 A251T gene polymorphisms were determined using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. Distributions of gene polymorphisms were evaluated according to the Hardy-Weinberg principle. Results: The TT genotype from the VEGF C936T genotype distributions was higher in the control group than in the DTC group (p < 0.05). In contrast, the IL-8 A-251T genotype distributions were similar in both groups. No relationship was found between either cytokine gene polymorphism or the DTC stages. The frequency of IL-8 TT was higher in the DTC group with lymph gland metastasis (TT 92%) than in the group without lymph gland metastasis (TT 45.9%) (p < 0.05). Conclusions: We consider that the VEGF 936 TT genotype may play a protective role in the development of DTC and that the IL-8 A-251 TT genotype may contribute to the DTC lymph node metastasis. Therefore, these genotypes may hold a key to the evaluation of thyroid nodules and the metastasis of DTC.en_US
dc.identifier.doi10.7754/Clin.Lab.2016.160403
dc.identifier.endpage2325en_US
dc.identifier.issn1433-6510
dc.identifier.issue12en_US
dc.identifier.pmid28164553en_US
dc.identifier.startpage2319en_US
dc.identifier.urihttps://doi.org/10.7754/Clin.Lab.2016.160403
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20494
dc.identifier.volume62en_US
dc.identifier.wosWOS:000390834800004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherClin Lab Publen_US
dc.relation.ispartofClinical Laboratoryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDifferentiated Thyroid Canceren_US
dc.subjectAngiogenesisen_US
dc.subjectIL-8 Gene Polymorphismen_US
dc.subjectVEGF Gene Polymorphismen_US
dc.subjectEndothelial Growth-Factoren_US
dc.subjectCell Lung-Canceren_US
dc.subjectTumor Angiogenesisen_US
dc.subjectGastric-Canceren_US
dc.subjectInterleukin-8 Promoteren_US
dc.subjectPooled Analysisen_US
dc.subjectIncreased Risken_US
dc.subjectCarcinomaen_US
dc.subjectExpressionen_US
dc.subjectAssociationen_US
dc.titleInvestigation of VEGF and IL-8 Gene Polymorphisms in Patients with Differentiated Thyroid Canceren_US
dc.typeArticleen_US

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