Serum insulin like growth factor-1 (IGF-1) and insulin like growth factor binding protein-3 (IGFBP-3) levels in liver cirrhosis

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dc.authoridKızıldağ, Servet/0000-0003-3565-279X
dc.authorwosidKızıldağ, Servet/AAV-9184-2020
dc.contributor.authorColakoglu, Oender
dc.contributor.authorTaskiran, Benguer
dc.contributor.authorColakoglu, Guel
dc.contributor.authorKizildag, Servet
dc.contributor.authorOezcan, Fulya Ari
dc.contributor.authorUensal, Belkis
dc.date.accessioned2024-06-12T10:56:15Z
dc.date.available2024-06-12T10:56:15Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground/aims: Impaired growth hormone-insulin like growth factor system in hepatic cirrhosis leads to cirrhosis-relaled complications. In this study, we aimed to investigate whether serum levels of insulin like growth factor-1 and insulin like growth factor binding protein-3 are related to the level of hepatic dysfunction, clinical grade, and etiologic factors of the disease in patients with liver cirrhosis. Methods: Forty-two patients with liver cirrhosis who were diagnosed by means of clinical findings, endoscopy, imaging studies, or histapathology were enrolled in the study. An age- and sex-matched control group was comprised of 37 healthy controls with no signs of liver disease by clinical or laboratory findings. The demographic features (age, sex, height, and weight) and serum levels of liver function tests, area, creatinine, sodium, potassium, insulin like growth factor-1, and insulin like growth factor binding protein-3 and hemogram values were recorded for each individual. The patients were grouped according to Child Pugh classification and etiology. Results: Insulin like growth factor-1 and insulin like growth factor binding protein-3 levels were significantly lower in the cirrhotic group in comparison to the control group (p<0.005). A statistically significaut decrease in levels of insulin like growth factor-1 and insulin like growth factor binding protein-3 was correlated with the degree of liver dysfunction, namely, lowest decrease in Child Pugh class A and highest decrease in class C. With respect to etiology, insulin like growth factor-1 levels of alcohol-related liver cirrhosis were significantly lower than those of hepatitis B-related cirrhosis. There was no relation between insulin like growth factor binding protein-3 level and etiology. In the cirrhotic group, insulin like growth factor-1 level was positively correlated with serum albumin and negatively correlated with serum creatinine and sodium levels and spleen size. Likewise, insulin like growth factor binding protein-3 level was positively correlated with serum albumin. There was a negative correlation between insulin like growth factor binding protein-3 level and serum bilirubin and spleen size. Conclusions: Insulin like growth factor-1 and insulin like growth factor binding protein-3 levels are related to the level of clinical impairment and were independent of the etiology. They may serve as novel markers of hepatocellular dysfunction.en_US
dc.identifier.endpage249en_US
dc.identifier.issn1300-4948
dc.identifier.issue4en_US
dc.identifier.pmid18080921en_US
dc.identifier.scopus2-s2.0-43549104721en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage245en_US
dc.identifier.trdizinid87853en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/87853
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19721
dc.identifier.volume18en_US
dc.identifier.wosWOS:000254610800005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Soc Gastroenterologyen_US
dc.relation.ispartofTurkish Journal Of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChild Classen_US
dc.subjectLiver Cirrhosisen_US
dc.subjectIGF-1en_US
dc.subjectIGFBP-3en_US
dc.subjectChronic-Renal-Failureen_US
dc.subjectTernary Complexen_US
dc.subjectHormoneen_US
dc.subjectRatsen_US
dc.subjectResistanceen_US
dc.subjectRetentionen_US
dc.subjectDiseaseen_US
dc.subjectSystemen_US
dc.titleSerum insulin like growth factor-1 (IGF-1) and insulin like growth factor binding protein-3 (IGFBP-3) levels in liver cirrhosisen_US
dc.typeArticleen_US

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