PREPARATION AND IN-VITRO CHARACTERIZATION OF CONTACT LENSES CONTAINING COENZYME Q10 LOADED MICELLES

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dc.authorscopusid57396839700
dc.contributor.authorErgin A.D.
dc.date.accessioned2024-06-12T10:25:58Z
dc.date.available2024-06-12T10:25:58Z
dc.date.issued2024
dc.description.abstractObjective: Coenzyme Q10 (CoQ10) offers potential therapeutic benefits for ocular health, yet faces challenges of poor solubility and bioavailability when applied to the eye. This study aimed to enhance CoQ10 delivery using contact lenses by incorporating CoQ10-loaded polymeric micelles, using Pluronic F127 and solvent evaporation technique. Material and Method: Polymeric micelles encapsulating CoQ10 were produced via solvent evaporation with Pluronic F127. Commercial contact lenses were subsequently loaded with these micelles. Characterization of the loaded lenses included assessments of light transmittance, swelling behavior, and drug release profile under non-sink conditions, simulating the constraints of the ocular surface. Result and Discussion: The unloaded lenses exhibited a light transmittance of 91.78±3.29% and swelling percentage of 47.51±4.45% while micelle-loaded lenses demonstrated high light transmittance levels (95.31±0.80%), ensuring optical clarity. Swelling studies showed a slight increase in size to 48.1±4.4%. The lenses effectively encapsulated 403.6±21.8 µg of CoQ10. In vitro release profile exhibited controlled release over six hours, indicating potential for sustained drug delivery. These results highlight the feasibility of micelle-loaded contact lenses for efficient ocular drug delivery, warranting further exploration into their long-term effectiveness and safety. © 2024 University of Ankara. All rights reserved.en_US
dc.description.sponsorshipTrakya University Scientific and Technological Research Council has provided the grant this research under the grant 2022/70. The author is grateful to Dr. Burcu Uner for size/zeta potential measurements.en_US
dc.identifier.doi10.33483/jfpau.1400373
dc.identifier.endpage188en_US
dc.identifier.issn2564-6524
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85184780795en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage179en_US
dc.identifier.trdizinid1222551en_US
dc.identifier.urihttps://doi.org/10.33483/jfpau.1400373
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1222551
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16610
dc.identifier.volume48en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherUniversity of Ankaraen_US
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoenzyme Q10; Contact Lens; Polymeric Micelle; Solubility Enhancementen_US
dc.subjectPoloxamer; Solvent; Ubidecarenone; Article; Controlled Drug Release; Controlled Study; Drug Delivery System; Drug Solubility; Evaporation; In Vitro Study; Light; Micellization; Nanoencapsulation; Size; Sustained Drug Releaseen_US
dc.titlePREPARATION AND IN-VITRO CHARACTERIZATION OF CONTACT LENSES CONTAINING COENZYME Q10 LOADED MICELLESen_US
dc.title.alternativeKOENZİM Q10 YÜKLÜ MİSEL İÇEREN KONTAKT LENSLERİN HAZIRLANMASI VE İN-VİTRO KARAKTERİZASYONUen_US
dc.typeArticleen_US

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