In Vitro Antioxidant and Enzyme Inhibition Activity of Tanacetum argyrophyllum (K. Koch) Tzvelev var. argyrophyllum Extract

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dc.authoridTABAN, KEVSER/0000-0001-8620-6402
dc.authorid, Nuraniye/0000-0002-4674-7009
dc.authorwosidTABAN, KEVSER/AGX-1201-2022
dc.contributor.authorEruygur, Nuraniye
dc.contributor.authorAkca, Keyser Taban
dc.contributor.authorUstun, Osman
dc.contributor.authorTekin, Mehmet
dc.date.accessioned2024-06-12T11:16:00Z
dc.date.available2024-06-12T11:16:00Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: Tanacetum L. belongs to Asteraceae family and is represented by 46 species in Turkiye. Tanacetum genus is known for its insecticide and insect repellent effect. T. argyrophyllum contains sesquiterpene lactone derivatives. These compounds are responsible for its various activities, especially cytotoxic, antitumor, phytotoxic, antimicrobial, antiviral, and antifungal activity. There are not enough biological activity studies on the plant that are likely to have a wide variety of activities in terms of the compounds it contains. The aim of the present study is to evaluate various biological activities of 80% aqueous methanol extract prepared from aerial parts of T. argyrophyllum (K. Koch) Tzvelev var. argyrophyllum collected from Sivas province of Turkey. Materials and Methods: Antioxidant activity of the methanol extract was determined by 2,2'-diphenyl-1-picryl-hydrazyl and 2,2-azinobis (3-ethyl benzothiazoline-6-sulfonic acid) radical scavenging activity, total phenolic, and total flavonoid content tests. Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities were investigated via Ellmans spectrometric method. Results: Total phenolic content was found as 71.67 mg/gallic acid equivalent g and total flavonoid content was 25.225 mg/quercetin equivalent g on dry extract weight basis. In this work, AChE, BChE, and alpha-glycosidase enzymes were inhibited by the extract of T. argyrophyllum var. argyrophyllum. IC50 values for these enzymes were found as 266.79 mu g/mL for AChE and 176.91 mu g/mL for BChE. Also, the alpha-glycosidase activity exhibited a dose-dependent manner with increasing concentration. Conclusion: According to the results, T. argyrophyllum var. argyrophyllum can be used as an ingredient of functional foods as well as herbal products for diabetic and Alzheimer's disease patients.en_US
dc.description.sponsorshipSivas Cumhuriyet University Scientific Research Projects (CUBAP) [ECZ26, ECZ31]en_US
dc.description.sponsorshipFinancial Disclosure: This study was partly funded by the Sivas Cumhuriyet University Scientific Research Projects (CUBAP no: ECZ26 and ECZ31) .en_US
dc.identifier.doi10.4274/tjps.galenos.2021.96493
dc.identifier.endpage382en_US
dc.identifier.issn1304-530X
dc.identifier.issn2148-6247
dc.identifier.issue4en_US
dc.identifier.pmid36047513en_US
dc.identifier.scopus2-s2.0-85137223795en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage377en_US
dc.identifier.trdizinid1125618en_US
dc.identifier.urihttps://doi.org/10.4274/tjps.galenos.2021.96493
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1125618
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24159
dc.identifier.volume19en_US
dc.identifier.wosWOS:000861213500002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofTurkish Journal Of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTanacetum Argyrophyllum Var. Argyrophyllumen_US
dc.subjectAntioxidanten_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectButyrylcholinesteraseen_US
dc.subjectAntidiabeticen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectAnticholinesteraseen_US
dc.subjectPartheniumen_US
dc.titleIn Vitro Antioxidant and Enzyme Inhibition Activity of Tanacetum argyrophyllum (K. Koch) Tzvelev var. argyrophyllum Extracten_US
dc.typeArticleen_US

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