The effect of low-dose external beam radiation on extraneural scarring after peripheral nerve surgery in rats

Basit Öğe Kaydı
dc.contributor.authorGörgülü, A
dc.contributor.authorUzal, C
dc.contributor.authorDoganay, L
dc.contributor.authorImer, M
dc.contributor.authorEliuz, K
dc.contributor.authorÇobanoglu, S
dc.date.accessioned2024-06-12T11:12:18Z
dc.date.available2024-06-12T11:12:18Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVE: Scar tissue is an inevitable result of peripheral nerve surgery. A variety of substances have been used to prevent epineurial scarring. In this study, the effect of low-dose radiation therapy on epineurial scarring was investigated. METHODS: Seventy-eight male Sprague-Dawley rats were studied. A total of 60 rats were subjected to one of three types of surgical procedure on the sciatic nerve, as follows: Procedure 1, external neurolysis (n = 20); Procedure 2, abrasive injury (n = 20); and Procedure 3, anastomosis (n = 20). On the left sciatic nerves, 700 cGy external beam radiation was administered 24 hours after surgery, and the right sciatic nerves served as a control group (surgery only). Eighteen animals without surgical intervention were used to establish the fibrotic effect of radiotherapy on normal nerves. A neurological examination was performed weekly. Six weeks after surgery, the extent of extraneural scarring was examined by gross microdissection by means of a numerical grading scheme and histological analysis. Cellular density and surface measurements of scar tissue were also evaluated. RESULTS: The dissection around the nerve was easier in rats treated with low-dose radiation compared with the control group. Furthermore, grading scores in both nerve adherence and nerve separability were significantly lower in treated nerves than in the control group (P less than or equal to 0.05). Low-dose radiotherapy decreased the scores of cellular density and surface measurement of scar tissue (P less than or equal to 0.05). In normal nerves, radio? therapy did not produce any fibrotic effects and the density of fibroblasts/fibrocytes was also very low. CONCLUSION: In the case of surgery or local trauma to peripheral nerve, the use of low-dose radiation therapy may be a safe method of limiting postoperative epineurial scar formation.en_US
dc.identifier.doi10.1227/01.NEU.0000093827.05319.E5
dc.identifier.endpage1395en_US
dc.identifier.issn0148-396X
dc.identifier.issue6en_US
dc.identifier.pmid14633305en_US
dc.identifier.scopus2-s2.0-10744230383en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1389en_US
dc.identifier.urihttps://doi.org/10.1227/01.NEU.0000093827.05319.E5
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23105
dc.identifier.volume53en_US
dc.identifier.wosWOS:000187176500032en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofNeurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPeripheral Nerveen_US
dc.subjectRadiationen_US
dc.subjectScaren_US
dc.subjectSciatic-Nerveen_US
dc.subjectMedian Nerveen_US
dc.subjectHeterotopic Ossificationen_US
dc.subjectLaminectomy Membraneen_US
dc.subjectPeridural Fibrosisen_US
dc.subjectPreventionen_US
dc.subjectIrradiationen_US
dc.subjectTherapyen_US
dc.subjectKeloidsen_US
dc.subjectModelen_US
dc.titleThe effect of low-dose external beam radiation on extraneural scarring after peripheral nerve surgery in ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu