The effect of hormone replacement therapy on haemostatic risk factors for cardiovascular disease
Küçük Resim Yok
Tarih
2000
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE: The aim of this study was to evaluate cardiovascular protective effects of oral and transdermal hormone replacement therapies on haemostatic risk factors for cardiovascular disease. STUDY DESIGN: This prospective randomized open study included 50 natural or surgical postmenopausal women. Of the 50 patients, 26 received hormone replacement therapy (HRT) consisting of 17-b estradiol and Norethindrone acetate (NETA) orally and 24 transdermally. Fibrinogen, factor VII and AT-III plasma levels were measured prior to therapy and in the third month of HRT and levels were compared statistically. RESULTS: A slightly but not statistically significant decrease of the plasma fibrinogen levels was observed in both oral and transdermal group. Although Factor VII levels decreased in both groups, this was statistically significant only in the transdermal group. In the transdermal group, factor VII level decreased from 0.421±0.14 gr/L to 0.293±8.15 gr/L (p<0.0001). Although a decrease of plasma AT-III levels has been observed also in transdermal group, this was not statistically significant. CONCLUSION: Our results show that during hormone replacement therapy factor VII levels decrease significantly by transdermal administration. However AT-III levels fall significantly by oral administration. Although a decrease of plasma AT-III levels has been observed also in transdermal group, this was not statistically significant. Falling levels of factor VII and fibrinogen, which are the most important two haemostatic cardiovascular risk factors, are supporting the preventative effects of hormone replacement therapy on cardiovascular disease.
Açıklama
Anahtar Kelimeler
Cardiovascular Disease; Haemostatic Factors; Hormone Replacement Therapy; Menopause, Antithrombin Iii; Blood Clotting Factor 7; Estradiol; Estradiol Plus Norethisterone Acetate; Fibrinogen; Norethisterone Acetate; Adult; Article; Cardiovascular Disease; Cardiovascular Risk; Clinical Article; Clinical Trial; Controlled Clinical Trial; Controlled Study; Female; Fibrinogen Blood Level; Heart Protection; Hemostasis; Hormone Substitution; Human; Postmenopause; Randomized Controlled Trial; Risk Factor
Kaynak
Jinekoloji ve Obstetrik Dergisi
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
14
Sayı
3
