Protective effects of ibuprofen on testicular torsion/detorsion-induced ischemia/reperfusion injury in rats

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dc.authoridYALCIN, OMER TARIK/0000-0001-5626-1881
dc.authoridbasaran, umit nusret/0000-0002-9977-6655
dc.authorwosidYALCIN, OMER TARIK/B-4744-2018
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.contributor.authorDokmeci, Dikmen
dc.contributor.authorKanter, Mehmet
dc.contributor.authorInan, Mustafa
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorBasaran, Umit Nusret
dc.contributor.authorYalcin, Omer
dc.contributor.authorTuran, Fatma Nesrin
dc.date.accessioned2024-06-12T11:07:07Z
dc.date.available2024-06-12T11:07:07Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the protective effect of ibuprofen on testicular torsion/detorsion induced ischemia/reperfusion (I/R) injury. A total of 48 prepubertal male Wistar albino rats were divided into two models: early and late orchiectomy. Testicular torsion was created by rotating the right testis 720 degrees in a clockwise direction. The ischemia period was 5 It and orchiectomy was performed after 5 h of detorsion in the early orchiectomy model (EOM). In the late orchiectomy model (LOM), the ischemia period was 5 It and orchiectomy was performed after 7 days of detorsion. In the EOM, ibuprofen (70 mg/kg, po) was administrated only once, 40 min prior to detorsion. In the LOM, ibuprofen (70 mg/kg, po) was administered 40 min before detorsion, once daily for 7 days. Bilateral orchiectomy was performed in all groups to measure the tissue levels of malondialdehyde (MDA) and to microscopically investigate, light and electrons. The presence of endothelial nitric oxide synthase (eNOS) activity was shown with immunohistochemical studies. Spermatogenesis and mean seminiferous tubule diameter (MSTD) were significantly decreased in ipsilateral and contralateral testis when both early band late I/R groups were compared to the sham groups. Furthermore, ibuprofentreated animals showed an improved histological appearance in both models of testicular torsion. lbuprofen treatment prevented lipid peroxidation resulting in decreased MDA accumulation in the testes of both models. After I/R, eNOS immunoreactivity was increased in the testicular tissues. lbuprofen treatment decreased eNOS immunoreactivity in the germ cells of the tubules in the contralateral testes, but intense eNOS immunoreactivity was shown in the ipsilateral testes of the LOM. Electron microscopy of the testes of rats demonstrated that ibuprofen pretreatment was particularly effective in preventing the mitochondrial degeneration in both Sertoli and spermatid cells in the LOM. Because of its anti -inflammatory and antioxidant effects, ibuprofen pretreatment may have protective effects in the experimental testicular torsion/detorsion model in rats.en_US
dc.identifier.doi10.1007/s00204-007-0189-2
dc.identifier.endpage663en_US
dc.identifier.issn0340-5761
dc.identifier.issn1432-0738
dc.identifier.issue9en_US
dc.identifier.pmid17345063en_US
dc.identifier.scopus2-s2.0-34547743397en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage655en_US
dc.identifier.urihttps://doi.org/10.1007/s00204-007-0189-2
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21911
dc.identifier.volume81en_US
dc.identifier.wosWOS:000249203300006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives Of Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIbuprofenen_US
dc.subjectTesticular Torsionen_US
dc.subjectIschemia/Reperfusionen_US
dc.subjectAntioxidanten_US
dc.subjectEnosen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectGerm-Cell Apoptosisen_US
dc.subjectOxidative Stressen_US
dc.subjectDelayed Phaseen_US
dc.subjectExpressionen_US
dc.subjectAspirinen_US
dc.subjectTorsionen_US
dc.subjectTestisen_US
dc.titleProtective effects of ibuprofen on testicular torsion/detorsion-induced ischemia/reperfusion injury in ratsen_US
dc.typeArticleen_US

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