MYRTUS COMMUNIS IMPROVES COGNITIVE IMPAIRMENT IN RENOVASCULAR HYPERTENSIVE RATS

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dc.authoridYegen, Berrak/0000-0003-0791-0165
dc.authoridKoyuncuoğlu, Türkan/0000-0003-4749-9470
dc.authoridYakut, Zatiye Ayça Çevikelli/0000-0002-6697-6781
dc.authoridKoyuncuoğlu, Türkan/0000-0003-4749-9470
dc.authoridSener, Goksel/0000-0001-7444-6193
dc.authorwosidErtas, Busra/IQS-8337-2023
dc.authorwosidYegen, Berrak/O-6652-2017
dc.authorwosidKoyuncuoğlu, Türkan/AAD-3448-2022
dc.authorwosidYakut, Zatiye Ayça Çevikelli/AAF-7800-2021
dc.authorwosidYakut, Zatiye Ayça Çevikelli/ACP-2487-2022
dc.authorwosidKoyuncuoğlu, Türkan/AAD-3962-2021
dc.contributor.authorCevikelli-Yakut, Z. -A.
dc.contributor.authorErtas, B.
dc.contributor.authorSen, A.
dc.contributor.authorKoyuncuoglu, T.
dc.contributor.authorYegen, B. C.
dc.contributor.authorSener, G.
dc.date.accessioned2024-06-12T11:13:36Z
dc.date.available2024-06-12T11:13:36Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMyrtus communis has anti-inflammatory, neuroprotective and anticholinesterase activities yet there have been limited studies examining effects of Myrtus communis on cognitive functions. This study investigated the possible effects of Myrtus communis on changes in the cognitive functions of experimental renovascular hypertensive rats. Fifty-six Wistar-Albino rats were equally divided into 4 groups; sham-operated control, renovascular hypertension (RVH), ramipril (RVH + Ram) and Myrtus communis extract (RVH + MC) treatment groups. Goldblatt's 2-kidney 1-clip (2K1C) method was used to induce RVH. At the end of 9 weeks of treatment, after blood pressure recording, the animals underwent new object recognition test and Morris water maze (MWM) task. Following these tests, blood brain barrier (BBB) integrity was examined in 6 animals from each group. In the others after decapitation, osteopontin and interleukin (IL)-10 levels were measured in blood samples; while matrix metalloproteinase (MMP)-13, sodium potassium adenosine triphosphatase (Na+,K+-ATPase), cluster of differentiation (CD) 36, amyloid beta (Ab), neprilysin levels, and acetylcholinesterase (AChE) activity were investigated in hippocampal tissues. In RVH group, high systolic blood pressure decreased serum IL-10 levels, increased serum osteopontin levels and also impaired BBB permeability. Hippocampal MMP-13, CD36, Ab, neprilysin levels and AChE activities were elevated, while there were decreases in Na+,K+-ATPase levels. In new objet recognition test, discrimination index (DI) was determined as lower in saline-treated RVH group compared to control animals. In MWM training trail, 4th day performance in finding platform was significantly reduced in saline-treated RVH group compared to control group. RVH also decreased the time spent in target quadrant in probe test of MWM task compared to control group. In both of the treatment groups, all biochemical parameters were restored in parallel with improvement in the behavioral test performances. The results of this study suggest that Myrtus communis extract may improve the cognitive dysfunctions in hypertension through antihypertensive, anti-inflammatory and anticholinesterase activities.en_US
dc.description.sponsorshipMarmara University Scientific Research Projects Committee [SAG-C-DRP-120418-0159]en_US
dc.description.sponsorshipThis study was funded by Marmara University Scientific Research Projects Committee with the grant number SAG-C-DRP-120418-0159.en_US
dc.identifier.doi10.26402/jpp.2020.5.07
dc.identifier.issn0867-5910
dc.identifier.issue5en_US
dc.identifier.pmid33475094en_US
dc.identifier.scopus2-s2.0-85100227551en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.26402/jpp.2020.5.07
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23597
dc.identifier.volume71en_US
dc.identifier.wosWOS:000613141400003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPolish Physiological Socen_US
dc.relation.ispartofJournal Of Physiology And Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRenovascular Hypertensionen_US
dc.subjectCognitive Impairmenten_US
dc.subjectBlood Brain Barrieren_US
dc.subjectAngiotensin IIen_US
dc.subjectRamiprilen_US
dc.subjectMyrtus Communisen_US
dc.subjectAmyloid Betaen_US
dc.subjectOsteopontinen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectAngiotensin-Converting Enzymeen_US
dc.subjectBrain-Barrier Impairmenten_US
dc.subjectOsteopontin Expressionen_US
dc.subjectAlzheimers-Diseaseen_US
dc.subjectOxidative Stressen_US
dc.subjectMemory Functionen_US
dc.subjectEssential Oilen_US
dc.subjectStrokeen_US
dc.subjectInhibitorsen_US
dc.subjectDysfunctionen_US
dc.titleMYRTUS COMMUNIS IMPROVES COGNITIVE IMPAIRMENT IN RENOVASCULAR HYPERTENSIVE RATSen_US
dc.typeArticleen_US

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