Decreased dickkopf-1 levels in chronic lymphocytic leukemia and increased osteopontin levels in non-Hodgkin's lymphoma at initial diagnosis: Could they be playing roles in pathogenesis?

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dc.authorwosidUyanik, Mehmet/AAD-7345-2020
dc.contributor.authorPamuk, Gulsum Emel
dc.contributor.authorUyanik, Mehmet Sevki
dc.contributor.authorPamuk, Omer Nuri
dc.contributor.authorMaden, Muhammet
dc.contributor.authorTapan, Umit
dc.date.accessioned2024-06-12T10:56:30Z
dc.date.available2024-06-12T10:56:30Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAims: We determined plasma levels of dickkopf-1 (DKK-1) and osteopontin (OPN) which have roles in the Wnt pathway in chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL) patients and in healthy controls. We also tested whether DKK-1 and OPN levels could be of clinical or prognostic significance in CLL and NHL. Methods: We included 36 CLL, 24 NHL patients, and 21 healthy controls. Patients' clinical and demographic features, treatment modalities, and response to treatment were recorded. DKK-1 and OPN levels in plasma obtained at initial diagnosis were determined with enzyme-linked immunosorbent assay. Results: CLL patients had significantly lower DKK-1 levels than NHL and control groups (P levels, respectively, 0.048 and 0.017). OPN level was significantly higher in NHL group than in CLL and control groups (P values, 0.017 and <0.001). CLL patients with early and late Rai stages of disease had similar DKK-1 and OPN levels. After a median follow-up of 48 months, 13 CLL patients died. Univariate analysis showed that advanced Rai stages and older age were significantly poor prognostic factors. DKK-1 level in CLL patients who have died was significantly lower than those who were alive (P = 0.035). NHL patients with extranodal involvement had significantly higher OPN levels than those with no involvement (P = 0.04). Conclusions: Our results demonstrated that the Wnt pathway inhibitor DKK-1 was decreased in CLL. OPN was increased in NHL and associated with extranodal involvement. In order to reveal the pathogenic and clinical roles of DKK-1 and OPN in CLL and NHL, larger studies need to be conducted.en_US
dc.description.sponsorshipRheumatology & Immunology Scientific Research Associationen_US
dc.description.sponsorshipThis work was supported by the Rheumatology & Immunology Scientific Research Association.en_US
dc.identifier.doi10.1179/1607845414Y.0000000205
dc.identifier.endpage271en_US
dc.identifier.issn1024-5332
dc.identifier.issn1607-8454
dc.identifier.issue5en_US
dc.identifier.pmid25271869en_US
dc.identifier.startpage267en_US
dc.identifier.urihttps://doi.org/10.1179/1607845414Y.0000000205
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19801
dc.identifier.volume20en_US
dc.identifier.wosWOS:000354411200004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherManey Publishingen_US
dc.relation.ispartofHematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Lymphocytic Leukemiaen_US
dc.subjectNon-Hodgkin's Lymphomaen_US
dc.subjectDickkopf-1en_US
dc.subjectOsteopontinen_US
dc.subjectExpressionen_US
dc.subjectReceptoren_US
dc.subjectMicroenvironmenten_US
dc.subjectPathwayen_US
dc.subjectCd44v6en_US
dc.subjectLiganden_US
dc.subjectCanceren_US
dc.subjectGenesen_US
dc.subjectCellsen_US
dc.subjectCllen_US
dc.titleDecreased dickkopf-1 levels in chronic lymphocytic leukemia and increased osteopontin levels in non-Hodgkin's lymphoma at initial diagnosis: Could they be playing roles in pathogenesis?en_US
dc.typeArticleen_US

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