Radiation-induced acute kidney toxicity: Protective effect of L-carnitine versus amifostine

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dc.authoridTürkkan, Görkem/0000-0002-9084-2599
dc.authoridArda, Ersan/0000-0002-5430-6561;
dc.authorwosidTürkkan, Görkem/E-7048-2017
dc.authorwosidArda, Ersan/L-7357-2016
dc.authorwosidTürkkan, Görkem/AAM-6705-2021
dc.contributor.authorYurut-Caloglu, V.
dc.contributor.authorCaloglu, M.
dc.contributor.authorDeniz-Yalta, T.
dc.contributor.authorAktoz, T.
dc.contributor.authorNurlu, D.
dc.contributor.authorKilic-Durankus, N.
dc.contributor.authorArda, E.
dc.date.accessioned2024-06-12T10:51:23Z
dc.date.available2024-06-12T10:51:23Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: The aim of the study was to compare the radioprotective efficacy in the kidney of L-carnitine to that of amifostine. Materials and Methods: Thirty three-month-old Wistar albino rats were randomly assigned to four groups: Group 1 (Control); Group 2 (Irradiation alone); Group 3 (amifostine plus irradiation); and Group 4 (L-carnitine before irradiation). The rats in Groups 2, 3, and 4 were irradiated individually with a single dose of 20 Gy to whole abdomen. L-carnitine (300 mg/kg) or amifostine (200 mg/kg) was administered 30 minutes before irradiation. Euthanasia was performed 5 days after irradiation, and kidneys were evaluated histopathologically. Results: Dilatation of Bowman's capsule, congestion of blood vessels, and tubular epithelial degeneration were significantly different among the groups (p < 0.05). Pretreatment with both L-carnitine and amifostine reduced the radiation-induced dilatation of Bowman's capsule (p < 0.05), congestion of blood vessels (p < 0.05), and tubular epithelial degeneration (p < 0.05). L-carnitine and amifostine were similar in protective effect. Conclusion: L-carnitine was equally effective as amifostine in protecting the kidney against acute irradiation damage.en_US
dc.identifier.doi10.7508/ijrr.2015.04.004
dc.identifier.endpage324en_US
dc.identifier.issn2322-3243
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84955239739en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage317en_US
dc.identifier.urihttps://doi.org/10.7508/ijrr.2015.04.004
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18350
dc.identifier.volume13en_US
dc.identifier.wosWOS:000369147400004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIjrr-Iranian Journal Radiation Resen_US
dc.relation.ispartofInternational Journal Of Radiation Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmifostineen_US
dc.subjectHistopathologyen_US
dc.subjectIrradiationen_US
dc.subjectKidneyen_US
dc.subjectL-Carnitineen_US
dc.subjectRadioprotectionen_US
dc.subjectL-Propionyl-Carnitineen_US
dc.subjectOxidative Stressen_US
dc.subjectRat Modelen_US
dc.subjectInjuryen_US
dc.subjectRadioprotectionen_US
dc.subjectRadiotherapyen_US
dc.subjectIrradiationen_US
dc.subjectNephropathyen_US
dc.subjectPreventionen_US
dc.subjectWr-2721en_US
dc.titleRadiation-induced acute kidney toxicity: Protective effect of L-carnitine versus amifostineen_US
dc.typeArticleen_US

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