99mTc-HMPAO brain perfusion single-photon emission computed tomography in children with Down syndrome

Simple item page
dc.authoridgültekin, aziz/0000-0002-0311-8077
dc.authorwosidgültekin, aziz/Q-9820-2018
dc.contributor.authorAltiay, Suriye
dc.contributor.authorKaya, Meryem
dc.contributor.authorKarasalihoglu, Serap
dc.contributor.authorGultekin, Aziz
dc.contributor.authorOner, Naci
dc.contributor.authorBiner, Betul
dc.date.accessioned2024-06-12T11:18:42Z
dc.date.available2024-06-12T11:18:42Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn recent years, it has been possible for patients with Down syndrome to live longer with advanced medical treatment and social support. As a result, the problems of these patients, such as thyroid diseases, leukemia, and Alzheimer disease, would be encountered more frequently. In this study, we aimed to perform the brain perfusion of children with Down syndrome by technetium 99m hexamethylpropylene amine oxime (Tc-99m-HMPAO) single-photon emission computed tomography (SPECT) and to determine the relationship between brain perfusion and epilepsy, thyroid function tests, congenital heart disease, and level of mental and motor development. Thirty patients with Down syndrome, aged between 1 and 15 years, were included in our study. Demographic data, the existence of epilepsy and congenital heart defects, the level of mental and motor development, serum. levels of thyroid hormones, and autoantibodies were determined. All patients underwent computed tomography (CT) and/or magnetic resonance imaging (MRI). Cerebral SPECT was per-formed in all cases to evaluate the brain perfusion pattern. According to the visual evaluation of cerebral SPECT results, hypoperfusion was detected in 11 cases (37%). Patients with cerebral hypoperfusion (group 1) and patients with normal cerebral perfusion (group 2) were compared. There was no difference between group 1 and group 2 in terms of demographic data, congenital heart defects, IQ levels, thyroid hormones, and autoantibodies, but the incidence of epilepsy was significantly higher in group 1 (P < .001). When motor and mental development levels were compared, it was found that cases in group 1 were significantly more retarded in personal-social and fine motor skills (P < .05). The present study showed that cerebral hypoperfusion in children with Down syndrome is mostly related to epilepsy and the other coexisting conditions, congenital heart disease and hypothyroidism. Patients with cerebral hypoperfusion also have more retarded developmental levels, especially in personal-social and fine motor skills.en_US
dc.identifier.doi10.1177/08830738060210070901
dc.identifier.endpage614en_US
dc.identifier.issn0883-0738
dc.identifier.issn1708-8283
dc.identifier.issue7en_US
dc.identifier.pmid16970855en_US
dc.identifier.scopus2-s2.0-33748064334en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage610en_US
dc.identifier.urihttps://doi.org/10.1177/08830738060210070901
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24932
dc.identifier.volume21en_US
dc.identifier.wosWOS:000239906000014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofJournal Of Child Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDevelopmental Screening Testen_US
dc.subjectTemporal-Lobe Epilepsyen_US
dc.subjectInterictal Specten_US
dc.subjectAlzheimers-Diseaseen_US
dc.subjectHypoperfusionen_US
dc.subjectDementiaen_US
dc.title99mTc-HMPAO brain perfusion single-photon emission computed tomography in children with Down syndromeen_US
dc.typeArticleen_US

Files

Collections

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu

We collect and process your personal information for the following purposes: Authentication, Preferences, Acknowledgement and Statistics.
To learn more, please read our privacy policy.

Customize