Evaluation of sleep quality of early buprenorphine/naloxone treatment in opioid addicted patients

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dc.authoridvardar, mehmet erdal/0000-0002-5836-6174;
dc.authorwosidvardar, mehmet erdal/ABI-5764-2020
dc.authorwosidvardar, mehmet erdal/AAB-7287-2021
dc.contributor.authorSipka, Huseyin
dc.contributor.authorVardar, Erdal
dc.date.accessioned2024-06-12T11:09:37Z
dc.date.available2024-06-12T11:09:37Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Opioid addiction is a chronic, relapsing and psychosocial disorder. In opioid addiction patients, studies show that sleep disorders, deteriorated quality of sleep and sleep architecture changes might be seen. In addition, comorbid psychiatric disorder and depression are frequently seen in opioid addicts. Comorbid psychiatric disorders and symptoms worsen of sleep quality in opioid addicts. This study aims to evaluate the quality of sleep during the periods of pre-treatment and in early opioid agonist maintenance treatment in the opioid addicts. Methods: The research included 29 patients in the Alcohol and Substance Addiction Treatment Unit of Trakya University Faculty of Medicine who have met diagnostic criteria for opioid addiction according to DSM-5, completed 28-day treatment, and admitted for control to Alcohol and Substance Addiction Treatment Unit after 1 month from discharge. The Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, Pittsburgh Sleep Quality Index are administered to all the patients who participated to the study on the day 1, day 28, and in the month 2. All the patients were treated with buprenorphine and naloxone combination. Results: In our study, a time-dependent significant decrease from day 1 to month 2 was determined in the average scores of the Pittsburgh Sleep Quality Index, which evaluates the sleep quality. In addition, the Pittsburgh Sleep Quality Index average scores showed differences in all time periods. Our study also determined a time-dependent significant decrease in the average scores of the Hamilton Depression Rating Scale and the Hamilton Anxiety Rating Scale, which evaluates respectively the depressive symptoms and anxiety symptoms on the day 0, day 28 and day 60. Discussion: In our research, we evaluated the sleep quality and the symptoms of depression and anxiety of the patients diagnosed with opioid addiction in pre-treatment and early period of opioid agonist maintenance treatment, and showed that those symptoms were getting better with treatment. We think that these findings can guide further research, as they show that opioid treatment does not only serve for addiction treatment but also for the treatment of the symptoms accompanying the opioid addiction.en_US
dc.identifier.doi10.5455/apd.294903
dc.identifier.endpage471en_US
dc.identifier.issn1302-6631
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85065204839en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage466en_US
dc.identifier.urihttps://doi.org/10.5455/apd.294903
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22885
dc.identifier.volume19en_US
dc.identifier.wosWOS:000447766200005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherCumhuriyet Univ Tip Fak Psikiyatri Anabilim Dalien_US
dc.relation.ispartofAnadolu Psikiyatri Dergisi-Anatolian Journal Of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOpioid Addictionen_US
dc.subjectSleepen_US
dc.subjectDepressionen_US
dc.subjectAnxietyen_US
dc.subjectBuprenorphineen_US
dc.subjectNaloxoneen_US
dc.subjectMaintained Patientsen_US
dc.subjectSubstance Useen_US
dc.subjectMethadoneen_US
dc.subjectSymptomsen_US
dc.subjectDependenceen_US
dc.subjectQuetiapineen_US
dc.subjectHeroinen_US
dc.subjectDetoxificationen_US
dc.subjectDisturbancesen_US
dc.subjectDepressionen_US
dc.titleEvaluation of sleep quality of early buprenorphine/naloxone treatment in opioid addicted patientsen_US
dc.typeArticleen_US

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