The prognostic significance of p21 and Her-2 gene expression and mutation/polymorphism in patients with gastric adenocarcinoma

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dc.authoridPuyan, Fulya/0000-0001-5853-0109
dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authoridIbis, Cem/0000-0002-5602-375X
dc.authoridOz Puyan, Fulya/0000-0001-5853-0109;
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.authorwosidKocak, Zafer/AEG-7828-2022
dc.authorwosidÖzen, Alaattin/ABG-9988-2020
dc.authorwosidÖzen, Alaattin/IZQ-0388-2023
dc.authorwosidIbis, Cem/AAE-3388-2020
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.authorwosidCAKINA, SUAT/AAA-2295-2020
dc.contributor.authorOzen, Alaattin
dc.contributor.authorKocak, Zafer
dc.contributor.authorSipahi, Tammam
dc.contributor.authorOz-Puyan, Fulya
dc.contributor.authorCakina, Suat
dc.contributor.authorSaynak, Mert
dc.contributor.authorIbis, Cem
dc.date.accessioned2024-06-12T11:11:55Z
dc.date.available2024-06-12T11:11:55Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAnalyses of gene expression status and genetic polymorphisms are methods to identify novel histopathological prognostic factors. In patients with gastric cancer, some cell cycle regulators p53, p21, p27 and Her-2 oncogene have been proposed as prognostic factors. We aimed to investigate the expression and mutation/polymorphism of p21 and Her-2 and also relationship between that genes status and histopathological factors and prognosis in patients with gastric cancer. Forty-four patients with locally advanced gastric cancer were analyzed in this study from January 2000 to December 2008. Clinicopathological parameters, expression and mutation/polymorphism of p21 and Her-2 results were used to predict disease-free survival and overall survival. The positive expression of p21 and Her-2 was observed in 61.4 % (n = 27) and 9.1 % (n = 4) of all 44 tumors, respectively. p21 gene mutation and Her-2 gene polymorphism were detected in 20 % (n = 11) and 2.3 % (n = 1, II phenotype) of cases, respectively. The negative expression of p21 was correlated significantly with diffuse and undifferential type histologies, whole gastric involvement and positive vascular/neural invasion. The median survival rate of patients with negative expression was significantly poorer than that of patients with positive expression of p21 (17 vs. 27 months, p = 0.01, cox regression). p21 mutation was significantly higher in patients with diffuse (p = 0.03) and undifferential (p = 0.02) type histologies. There was no statistically significant association between histopathological parameters and Her-2 gene polymorphism/expression. The negative expression of p21 correlates with disease survival and may be a poor prognostic factor in patients with resected gastric cancer treated with adjuvant chemotherapy.en_US
dc.description.sponsorshipTrakya Universityen_US
dc.description.sponsorshipThis study was supported by Trakya University Scientific Research Projects Unit in the program year of 2010.en_US
dc.identifier.doi10.1007/s12032-012-0357-y
dc.identifier.issn1357-0560
dc.identifier.issn1559-131X
dc.identifier.issue1en_US
dc.identifier.pmid23275116en_US
dc.identifier.scopus2-s2.0-84880585642en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s12032-012-0357-y
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22980
dc.identifier.volume30en_US
dc.identifier.wosWOS:000316800800037en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofMedical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectP21 Expressionen_US
dc.subjectP21 Gene Mutationen_US
dc.subjectHer-2 Expressionen_US
dc.subjectHer-2 Gene Polymorphismen_US
dc.subjectGastric Adenocarcinomaen_US
dc.subjectC-Erbb-2 Protein Expressionen_US
dc.subjectShort-Term Prognosisen_US
dc.subjectCyclin-Een_US
dc.subjectCanceren_US
dc.subjectCarcinomaen_US
dc.subjectP53en_US
dc.subjectP21(Waf1/Cip1)en_US
dc.subjectInhibitoren_US
dc.subjectWaf1/Cip1en_US
dc.subjectStomachen_US
dc.titleThe prognostic significance of p21 and Her-2 gene expression and mutation/polymorphism in patients with gastric adenocarcinomaen_US
dc.typeArticleen_US

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