Antikardiolipin pozitif ve negatif olan sistemik lupus eritematozus hastalarında erken kardiyak disfonksiyonun değerlendirilmesi
Yükleniyor...
Dosyalar
Tarih
2010
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Trakya Üniversitesi Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Çalışmamızda kardiyak açıdan asemptomatik sistemik lupus eritematozus hastalarında antikardiolipin antikor pozitifliği ile erken kardiyak fonksiyon bozukluğu arasındaki ilişkiyi araştırmayı planladık. Çalışmaya 50 hasta ve 30 kontrol grubu alındı. Sistemik lupus eritematozus hastaları antikardiolipin pozitif ve negatif olarak iki gruba bölündü Çalışmamızda standart Doppler ve doku Doppler görüntüleme parametreleri analiz edildi.. Sonuçta antikardiolipin pozitif olan grupta sistolik fonksiyon göstergesi olan doku Doppler sistolik ejeksiyon S dalgası daha düşük olarak bulundu (p=0.021). Diyastolik fonksiyon bozukluğunun göstergesi olan sol atrıum boyutu antikardiolipin pozitif olan grupta daha büyük bulundu (p=0.031) Antikardiolipin antikor pozitifliğinin Em ile anlamlı düzeyde negatif ilişkili olduğu görüldü (p<0.024, r= -0.32). Antikardiolipin antikor pozitifliğinin ortalama karotis intima media kalınlığı ile anlamlı düzeyde pozitif ilişkili olduğu saptandı (p=0.011, r=0.358). Sonuç olarak kardiyak açıdan asemptomatik antikardiolipin antikor pozitif sistemik lupus eritematozuslu hastalarda longitudinal sol ventrikül sistolik ve diyastolik fonksiyonları normal sınırlar içerisinde olmasına karşın sağlıklı popülasyona göre azalmıştır. Longitudinal sol ventrikül fonksiyonu, miyokard hasarlanma derecesiyle ilişkilidir. Sol ventrikül longitudinal fonksiyonlarındaki bu azalmanın antikardiolipin antikor pozitifliği olan hastalarda oluşabilen subklinik ateroskleroz ve inflamasyona sekonder hücre hasarına bağlı olduğunu düşünmekteyiz.
Abstract
We aimed to investigate anticardiolipin positive or negative asymptomatic systemic lupus erytematosus patients early cardiac dysfunction by using echocardiography.. Fifty patients providing the exclusion criteria who has performed echocardiography before were investigated. Control group was consisted of thirty patients who have never been investigated by echodardiography because of any primary or secondary cardiac disease. In our study standart Doppler and tissue Doppler were investigated. Patients were divided into two groups such as anticardiolipin positive or negative. Echocardiographic data's of patients were compared between each other and between the control group.. In results as an indicator of systolic functions, systolic S wave by tissue doppler was statistically decreased in anticardiolipin positive group than the anticardiolipin negative group. And as an indicator of dystolic disfunctions; left atrium dimensions statistically were greater in the anticardiolipin positive group than the negative group. In conclusion, the longitudinal left ventricule systolic and diastolic functions are in normal ranges at asymptomatic systemic lupus erythematosus patients according to the healthy population but also there is a reduction. Longitudinal left ventricule functions are considerably related with the changing damage degree. It is demonstrated that the decrese at tissue doppler imaging is a marker of cardiac impairment. We think that the decrease of left ventricul longitudinal functions is due the subclinical atherosclerosis and inflamation which causes secondary cell injury at anticardiolipin antibody positive systemic lupus erythematosus patients .
Abstract
We aimed to investigate anticardiolipin positive or negative asymptomatic systemic lupus erytematosus patients early cardiac dysfunction by using echocardiography.. Fifty patients providing the exclusion criteria who has performed echocardiography before were investigated. Control group was consisted of thirty patients who have never been investigated by echodardiography because of any primary or secondary cardiac disease. In our study standart Doppler and tissue Doppler were investigated. Patients were divided into two groups such as anticardiolipin positive or negative. Echocardiographic data's of patients were compared between each other and between the control group.. In results as an indicator of systolic functions, systolic S wave by tissue doppler was statistically decreased in anticardiolipin positive group than the anticardiolipin negative group. And as an indicator of dystolic disfunctions; left atrium dimensions statistically were greater in the anticardiolipin positive group than the negative group. In conclusion, the longitudinal left ventricule systolic and diastolic functions are in normal ranges at asymptomatic systemic lupus erythematosus patients according to the healthy population but also there is a reduction. Longitudinal left ventricule functions are considerably related with the changing damage degree. It is demonstrated that the decrese at tissue doppler imaging is a marker of cardiac impairment. We think that the decrease of left ventricul longitudinal functions is due the subclinical atherosclerosis and inflamation which causes secondary cell injury at anticardiolipin antibody positive systemic lupus erythematosus patients .
Açıklama
Tıpta Uzmanlık Tezi
Anahtar Kelimeler
Kardiyoloji, Cardiology, Romatoloji, Rheumatology, Kalp Damar Sistemi Hastalıkları, Tıp Bilimleri, Sistemik Lupus Eritematozus, Erken Kardiyak Disfonksiyonu, Doku Doppler İnceleme, Antikardiolipin Antikor, Systemic Lupus Erythematosus, Tissue Doppler, Anticardiolipin Antibody, Early Cardiac Disfunction
