DEVELOPMENT AND VALIDATION OF HPLC ANALYTICAL METHODS USED FOR DETERMINATION OF ASSAY, CONTENT UNIFORMITY AND DISSOLUTION OF IMMEDIATE RELEASE CANDESARTAN CILEXETIL 32 MG TABLETS

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dc.authoridYUCE, MERAL/0000-0003-0393-1225
dc.authoridCapan, Yilmaz/0000-0003-1234-9018
dc.authorwosidÇapan, Yılmaz/AAM-5292-2021
dc.contributor.authorYuce, Meral
dc.contributor.authorCapan, Yilmaz
dc.date.accessioned2024-06-12T10:52:38Z
dc.date.available2024-06-12T10:52:38Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractNew analytical methods have been developed and validated on high performance liquid chromatography (HPLC) to assess the assay, content uniformity and dissolution of immediate release candesartan cilexetil 32 mg tablets. Method development studies were performed on cyano column. Mobile phase of assay and content uniformity test consisted of mixture of 0.05 M phosphate buffer, pH 4.5 and methanol (40 : 60, v/v) adjusted to pH 4.0 with trifluoroacetic acid, whereas mobile phase of dissolution test consisted of mixture of I mM phosphate buffer and acetonitrile (50 : 50, v/v) adjusted to pH 2.0 with tritluoroacetic acid. Mobile phases were pumped at flow rate of 1.0 mL/min, ultraviolet-visible (UV) detector was operated at 254 nm. injection volume was set at 20 mu L. column temperature was held at 25 degrees C. Dissolution medium was 0.05 M phosphate buffer, pH 6.5 including 0.70% (w/v) polysorbate 20. Validation studies met acceptance criteria of system suitability, specificity. linearity and range, accuracy, precision. detection limit (LOD). quantitation limit (LOQ) and robustness parameters.en_US
dc.identifier.endpage367en_US
dc.identifier.issn0001-6837
dc.identifier.issn2353-5288
dc.identifier.issue2en_US
dc.identifier.pmid29624240en_US
dc.identifier.startpage357en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18782
dc.identifier.volume74en_US
dc.identifier.wosWOS:000430449900005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPolskie Towarzystwo Farmaceutyczneen_US
dc.relation.ispartofActa Poloniae Pharmaceuticaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAssayen_US
dc.subjectCandesartan Cilexetilen_US
dc.subjectContent Uniformityen_US
dc.subjectDissolutionen_US
dc.subjectMethod Validationen_US
dc.subjectTableten_US
dc.titleDEVELOPMENT AND VALIDATION OF HPLC ANALYTICAL METHODS USED FOR DETERMINATION OF ASSAY, CONTENT UNIFORMITY AND DISSOLUTION OF IMMEDIATE RELEASE CANDESARTAN CILEXETIL 32 MG TABLETSen_US
dc.typeArticleen_US

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