Cytotoxic effect of Cotinus coggygria extract on Hep3B cancer cell line

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dc.authoridDanjolli-Hashani, Dua/0000-0002-7377-6518
dc.authorwosidDanjolli-Hashani, Dua/IQV-2684-2023
dc.contributor.authorDanjolli-Hashani, Dua
dc.contributor.authorSelen-Isbilir, Sebnem
dc.date.accessioned2024-06-12T10:58:40Z
dc.date.available2024-06-12T10:58:40Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCotinus coggygria Scop. is a medicinal plant which contains a variety of precious phytochemical compounds applicable in traditional medicine. The aim of this study is to investigate the cytotoxic effect of Cotinus coggygria extract on Hep3B cancer cells. The cytotoxic effect was measured by MTT assay. Based on IC50 values, the C. coggygria leaf extract showed cytotoxic effect on Hep3B cancer cells, which was found better at 24 h (IC50 = 3.642) then at 48 h (IC50 = 3.956). Also, the dose of C. coggygria extract showed negative correlation (p < 0.05) with cell viability of 24 h and 48 h and positive correlation (p < 0.05) with cytotoxic effect of 24 h and 48 h. The cytotoxic effects were concentration-time dependent. According to our study, C. coggygria extract had protective effect at 24 h on AML12 cell line and cytotoxic effect on the Hep3B cancer cell line, where it indicates that it may have an antitumorigenic effect.en_US
dc.description.sponsorshipScientific Research Fund ofTrakya University [TUBAP-2019/159]en_US
dc.description.sponsorshipThe authors wish to thank Technology Research Development Application and Research Center(TUTAGEM) for the MTT assay. The authors are grateful to Dr. Necmettin Guler for the taxonomicidentity of the plant. This work was supported financially by the; Scientific Research Fund ofTrakya University, Project number TUBAP-2019/159en_US
dc.identifier.doi10.1080/14786419.2022.2158462
dc.identifier.endpage4007en_US
dc.identifier.issn1478-6419
dc.identifier.issn1478-6427
dc.identifier.issue23en_US
dc.identifier.pmid36533684en_US
dc.identifier.scopus2-s2.0-85144275361en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage4004en_US
dc.identifier.urihttps://doi.org/10.1080/14786419.2022.2158462
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20154
dc.identifier.volume37en_US
dc.identifier.wosWOS:000900025300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNatural Product Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCotinus Coggygriaen_US
dc.subjectCytotoxic Effecten_US
dc.subjectHep3Ben_US
dc.subjectAML12en_US
dc.subjectApoptosisen_US
dc.subjectConstituentsen_US
dc.titleCytotoxic effect of Cotinus coggygria extract on Hep3B cancer cell lineen_US
dc.typeArticleen_US

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