Potential genotoxicity of acetamiprid and propineb singly or in combination in cultured human peripheral blood lymphocytes by using MN assay

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dc.authorscopusid8241190000
dc.authorscopusid15136582600
dc.authorscopusid36150926700
dc.authorscopusid56707507900
dc.authorscopusid56707000600
dc.contributor.authorGokalp Muranli F.D.
dc.contributor.authorRasgele P.G.
dc.contributor.authorKekecoglu M.
dc.contributor.authorKanev M.
dc.contributor.authorOzdemir K.
dc.date.accessioned2024-06-12T10:28:22Z
dc.date.available2024-06-12T10:28:22Z
dc.date.issued2015
dc.description.abstractAcetamiprid, a neonicotinoid insecticide, and Propineb, a dithicarbamate fungicide, are used in agriculture singly or in combination with other pesticides. The aim of the study is to investigate the single and combined genotoxic effect two pesticides on cultured human lymphocytes by using the Micronucleus (MN) assay. The lymphocytes were treated with three different concentrations of pesticides singly and in combination (a mix), Acetamiprid (0.625, 1.25, 2.5 ug mL-1), Propineb (12.5, 25, 50 ?g mL-1) and Acetamiprid+Propineb (0.625+12.5, 1.25+25, 2.5+50 ?g mL-1), for 24 and 48 hours. MN frequency significantly increased at a 48-hour exposure period when the lymphocytes were exposed to the combined pesticides. The data demonstrated that these pesticides may have a synergistic effect and may have potential genotoxic activity in cultured human lymphocytes. Also, it was shown that when they are combined and exposed to lymphocytes these pesticides have a cytotoxic effect.en_US
dc.identifier.endpage3955en_US
dc.identifier.issn1018-4619
dc.identifier.issue11Ben_US
dc.identifier.scopus2-s2.0-84957823982en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage3947en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17213
dc.identifier.volume24en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publicationsen_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetamiprid; Human Lymphocyte Culture; In Vitro; Propineben_US
dc.subjectBioassay; Blood; Cells And Cell Components; Chemical Compound; Concentration (Composition); Fungicide; Genotoxicity; Neonicotinoid Pesticideen_US
dc.titlePotential genotoxicity of acetamiprid and propineb singly or in combination in cultured human peripheral blood lymphocytes by using MN assayen_US
dc.typeArticleen_US

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