Oxidative stress, male infertility and the role of carnitines.

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dc.authorscopusid6602917963
dc.contributor.authorDokmeci D.
dc.date.accessioned2024-06-12T10:28:00Z
dc.date.available2024-06-12T10:28:00Z
dc.date.issued2005
dc.description.abstractOxidative stress has been shown to be a major cause of male infertility; a large proportion of infertile men have elevated levels of seminal reactive oxygen species (ROS). High concentrations of ROS cause sperm pathology such as ATP depletion leading to insufficient axonemal phosphorylation, lipid peroxidation and loss of motility and viability. L-carnitine, a naturally occurring enzymatic antioxidant, is a necessary factor in the utilization of long chain fatty acids to produce energy. Furthermore, it plays a pivotal role in the maturation of spermatozoa within the male reproductive tract. Epididymal plasma contains the highest levels of L-carnitine found in the human body, and initiation of sperm motility occurs in parallel to L-carnitine increase in the epididymal lumen. It is known that L-carnitine prevents the formation of ROS, scavenges free radicals and protects cells from peroxidative stress. Moreover, it plays a key role in sperm metabolism by providing readily available energy for use by spermatozoa, which positively affects sperm motility, maturation and the spermatogenic process. L-carnitine and its derivatives have been proposed recently for treatment of male infertility, and a number of controlled and uncontrolled human and animal studies have been conducted to indicate their possible application. As a result, antioxidant therapy with carnitines may represent a new nonhormonal option within a broader therapeutic strategy in men with ROS-mediated infertility.en_US
dc.identifier.endpage30en_US
dc.identifier.issn0204-8043
dc.identifier.issue1en_US
dc.identifier.pmid16152768en_US
dc.identifier.scopus2-s2.0-25444509267en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage26en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17038
dc.identifier.volume47en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofFolia medicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant; Carnitine; Reactive Oxygen Metabolite; Human; Male; Male Infertility; Metabolism; Oxidative Stress; Review; Antioxidants; Carnitine; Humans; Infertility, Male; Male; Oxidative Stress; Reactive Oxygen Speciesen_US
dc.titleOxidative stress, male infertility and the role of carnitines.en_US
dc.typeReview Articleen_US

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