The Role of 5-Hydroxymethylcytosine as a Potential Epigenetic Biomarker in a Large Series of Thyroid Neoplasms

Basit Öğe Kaydı
dc.authoridCanberk, Sule/0000-0002-3736-1323
dc.authoridCanberk, Sule/0000-0002-3736-1323
dc.authoridMaximo, Valdemar/0000-0002-8631-8356
dc.authoridSoares, Paula/0000-0001-9607-6998
dc.authoridMaximo, Valdemar/0000-0002-8631-8356
dc.authorwosidCanberk, Sule/AAL-5645-2020
dc.authorwosidCanberk, Sule/AAM-8781-2020
dc.authorwosidMaximo, Valdemar/HPD-4236-2023
dc.authorwosidSoares, Paula/B-6054-2008
dc.authorwosidMaximo, Valdemar/E-7480-2011
dc.contributor.authorCanberk, Sule
dc.contributor.authorGoncalves, Joao
dc.contributor.authorRios, Elisabete
dc.contributor.authorPovoa, Antonia A.
dc.contributor.authorTastekin, Ebru
dc.contributor.authorSobrinho-Simoes, Manuel
dc.contributor.authorUguz, Aysun
dc.date.accessioned2024-06-12T11:16:25Z
dc.date.available2024-06-12T11:16:25Z
dc.date.issued2024
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCytosine modifications at the 5-carbon position play a critical role in gene expression regulation and have been implicated in cancer development. 5-Hydroxymethylcytosine (5hmC), arising from 5-methylcytosine (5-mC) oxidation, has shown promise as a potential malignancy marker due to its depletion in various human cancers. However, its significance in thyroid tumors remains underexplored, primarily due to limited data. In our study, we evaluated 5hmC expression levels by immunohistochemistry in a cohort of 318 thyroid tumors. Our analysis revealed significant correlations between 5hmC staining extension scores and nodule size, vascular invasion, and oncocytic morphology. Nuclear 5hmC staining intensity demonstrated associations with focality, capsule status, extrathyroidal extension, vascular invasion, and oncocytic morphology. Follicular/oncocytic adenomas exhibited higher 5hmC expression than uncertain malignant potential (UMP) or noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP), as well as malignant neoplasms, including papillary thyroid carcinomas (PTCs), oncocytic carcinomas (OCAs), follicular thyroid carcinomas (FTCs), and invasive encapsulated follicular variants of PTC (IEFV-PTC). TERT promoter mutation cases showed notably lower values for the 5hmC expression, while RAS (H, N, or K) mutations, particularly HRAS mutations, were associated with higher 5hmC expression. Additionally, we identified, for the first time, a significant link between 5hmC expression and oncocytic morphology. However, despite the merits of these discoveries, we acknowledge that 5hmC currently cannot segregate minimally invasive from widely invasive tumors, although 5hmC levels were lower in wi-FPTCs. Further research is needed to explore the potential clinical implications of 5hmC in thyroid tumors.en_US
dc.description.sponsorshipFCT-Fundao para a Cincia e a Tecnologia-en_US
dc.description.sponsorshipNo Statement Availableen_US
dc.identifier.doi10.1007/s12022-024-09800-9
dc.identifier.endpage39en_US
dc.identifier.issn1046-3976
dc.identifier.issn1559-0097
dc.identifier.issue1en_US
dc.identifier.pmid38285158en_US
dc.identifier.scopus2-s2.0-85183365237en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage25en_US
dc.identifier.urihttps://doi.org/10.1007/s12022-024-09800-9
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24298
dc.identifier.volume35en_US
dc.identifier.wosWOS:001150409900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofEndocrine Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThyroid Tumorsen_US
dc.subjectHurthle Cell Tumoren_US
dc.subjectOncocytic Cell Tumorsen_US
dc.subjectEpigeneticsen_US
dc.subject5hmcen_US
dc.subjectPoor Survivalen_US
dc.subjectInhibitionen_US
dc.subjectPrognosisen_US
dc.titleThe Role of 5-Hydroxymethylcytosine as a Potential Epigenetic Biomarker in a Large Series of Thyroid Neoplasmsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu