The molecular epidemiology of trimethoprim-sulphamethoxazole-resistance of Shigella flexneri in the Trakya region of Turkey

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dc.authoridVahaboglu, H/0000-0001-8217-1767
dc.authorwosidVahaboglu, H/HHZ-1169-2022
dc.contributor.authorOtkun, M
dc.contributor.authorAkata, F
dc.contributor.authorVahaboglu, H
dc.contributor.authorTatmanOtkun, M
dc.contributor.authorTugrul, M
dc.contributor.authorDundar, V
dc.date.accessioned2024-06-12T11:16:42Z
dc.date.available2024-06-12T11:16:42Z
dc.date.issued1997
dc.departmentTrakya Üniversitesien_US
dc.description.abstractTrimethoprim-sulphamethoxazole (SXT) resistance increased among Shigella flexneri isolates in 1995 relative to previous years, in the Trakya region, the European part of Turkey. Since this region is the entrance to Turkey from northern countries, a heavy traffic of travellers passing through should have been importing or exporting the resistant isolates. We studied the genetic basis and epidemiology of this resistance and monitored the clonal changes which have taken place in the meanwhile. During the study period, a total of 70 Shigella spp. were isolated. Of these 58 were S. flexneri, 10 were S. sonnei and two were S. boydii. S. dysenteriae was not isolated. Of S. flexneri isolates 32 were SXT, ampicillin, chloramphenicol and tetracycline resistant (pattern I), while two isolates were found to be resistant only to SXT (Pattern II). Transconjugation experiments revealed that an approximately 80 Kbp self-transmissible plasmid carried the SXT resistance genes in both groups. However, EcoRI and HindIII restriction patterns of the plasmids from resistance pattern I and resistance pattern II were different. Ribotypes of three randomly selected isolates from pattern I were identical and were distinguishable from the ribotype of the isolate from pattern II. We concluded that at least two different clones with different plasmids and resistance patterns were spreading in our territory.en_US
dc.identifier.endpage231en_US
dc.identifier.issn1121-7138
dc.identifier.issue3en_US
dc.identifier.pmid9258942en_US
dc.identifier.scopus2-s2.0-0031181180en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage227en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24414
dc.identifier.volume20en_US
dc.identifier.wosWOS:A1997XM77000007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLuigi Ponzio E Figlioen_US
dc.relation.ispartofMicrobiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTrimethoprim-Sulphamethaxazole Resistanceen_US
dc.subjectShigella Flexnerien_US
dc.subjectPlasmiden_US
dc.subjectRibotypingen_US
dc.subjectAntimicrobial Resistanceen_US
dc.subjectPlasmiden_US
dc.subjectSonneien_US
dc.subjectDnaen_US
dc.titleThe molecular epidemiology of trimethoprim-sulphamethoxazole-resistance of Shigella flexneri in the Trakya region of Turkeyen_US
dc.typeArticleen_US

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