L-carnitine inhibits ethanol-induced gastric mucosal injury in rats

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dc.authoridAkpolat Ferah, Meryem/0000-0002-3419-1728;
dc.authorwosidAkpolat Ferah, Meryem/ABD-3035-2020
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.contributor.authorDokmeci, D
dc.contributor.authorAkpolat, M
dc.contributor.authorAydogdu, N
dc.contributor.authorDoganay, L
dc.contributor.authorTuran, FN
dc.date.accessioned2024-06-12T10:55:47Z
dc.date.available2024-06-12T10:55:47Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractL-carnitine is a quaternary amine that is essential for the normal oxidation of long-chain fatty acids by mitochondria. It is known that L-carnitine and its derivatives prevent the formation of reactive oxygen species, scavenge free radicals and protect cells from peroxidative stress. Oxygen-derived free radicals and lipid peroxidation products play a critical role in the pathogenesis of ethanol-induced gastric mucosal injury. The aim of the present study was to determine the effect of L-camitine on lipid peroxidation induced by ethanol in the rat stomach. In our study, gastric mucosal injury was induced by the intragastric administration of 1 ml of absolute ethanol. Test compounds were given to rats by gavage 30 min before the ethanol administration. The animals were killed 60 min after the administration of ethanol. The stomach of each animal was removed. Mucosal damage was evaluated by macroscopic examination, histological analysis and by measurement of lipid peroxidation and glutathione activity. The intragastric administration of ethanol induced hyperemia and hemorrhagic erosions in the rat stomachs. L-camitine significantly prevented gastric ulcerogenesis induced by ethanol and decreased the ulcer index. Plasma and gastric lipid peroxidation that was increased significantly by ethanol was decreased after treatment with L-camitine. Ethanol treatment decreased significantly the gastric glutathione levels, and pretreatment with L-camitine increased them significantly. Based on these data, the beneficial effects of L-camitine on ethanol-induced gastric mucosal injury may be attributed to its antiperoxidative effects.en_US
dc.identifier.endpage488en_US
dc.identifier.issn1734-1140
dc.identifier.issn2299-5684
dc.identifier.issue4en_US
dc.identifier.pmid16129915en_US
dc.identifier.scopus2-s2.0-24744433565en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage481en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19559
dc.identifier.volume57en_US
dc.identifier.wosWOS:000231926300005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofPharmacological Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarnitineen_US
dc.subjectEthanolen_US
dc.subjectGastric Mocosal Injuryen_US
dc.subjectLipid Peroxidationen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectInduced Lipid-Peroxidationen_US
dc.subjectPropionyl-L-Carnitineen_US
dc.subjectAcetyl-L-Carnitineen_US
dc.subjectAciden_US
dc.subjectDamageen_US
dc.subjectStressen_US
dc.subjectProtectionen_US
dc.subjectMechanismen_US
dc.subjectUlcersen_US
dc.titleL-carnitine inhibits ethanol-induced gastric mucosal injury in ratsen_US
dc.typeArticleen_US

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