COMPARISON OF SOME BIOLOGICAL ACTIVITIES AND CATECHIN TANNIN CONTENTS OF TWO JUNIPERUS AND PRUNUS SPECIES
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
University of Ankara
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Qualitative and quantitative determination of catechin in fruits of J. communis var. saxatilis, J. oxycedrus subsp. oxycedrus, P. spinosa, and P. cerasifera was analyzed by LC-MS/MS using standards. Antidiabetic, antimicrobial, and antioxidant activities of fruit and cone extracts of these plants were evaluated. Qualitative analysis of secondary metabolites was also done. Material and Method: Antimicrobial activity was done with MIC. ABTS·+ and DPPH• scavenging activies were used antioxidant activity. ?-Amylase and ?-glucosidase inhibition assays were done for antidiabetic activity. Result and Discussion: JCS (IC50 = 578 ± 20 ?g/ml), JOO (IC50 = 3706 ± 52 ?g/ml), and PS (IC50 = 313 ± 7 ?g/ml) extracts were observed to show a higher activity than acarbose (IC50 = 4061 ± 146 ?g/ml). J. communis var. saxatilis fruit extract was observed with MIC values between (312.5 - 2500 µg/ml) against all microorganisms. JCS extract has the highest phenolic composition and JOO has the lowest phenolic composition (µg GAE/ mg extract). JCS extract indicated the highest antioxidant activity. It was determined that plant containing the highest catechin (1173.3±5.77 ng/ml) and epigallocatechin (208±7.21 ng/ml) was JCS. In this research, it can be said that JCS with the highest tannin content shows the highest effects. © 2023 University of Ankara. All rights reserved.
Açıklama
Anahtar Kelimeler
Antidiabetic; Antimicrobial; Catechic; Juniperus; Prunus, Acarbose; Alkaloid Derivative; Alpha Glucosidase; Alpha Glucosidase Inhibitor; Alpha Tocopherol; Ampicillin; Amylase; Amylase Inhibitor; Anthocyanoside Derivative; Anthracene Derivative; Antibiotic Agent; Antidiabetic Agent; Antifungal Agent; Antioxidant; Catechin; Coumarin Derivative; Epicatechin Gallate; Epigallocatechin; Epigallocatechin Gallate; Flavonoid; Juniperus Communis Var. Saxatilis Extract; Juniperus Oxycedrus Subsp. Oxycedrus Extract; Methanol; Phenol Derivative; Plant Extract; Plant Resin; Prunus Cerasifera Extract; Prunus Spinosa Extract; Saponin Derivative; Tannin Derivative; Terbinafine; Trolox C; Unclassified Drug; Abts Radical Scavenging Assay; Antibacterial Activity; Antidiabetic Activity; Antifungal Activity; Antioxidant Activity; Article; Bacillus Subtilis; Candida Albicans; Candida Parapsilosis; Colony Forming Unit; Comparative Study; Controlled Study; Dpph Radical Scavenging Assay; Drug Isolation; Enterobacter Aerogenes; Enzyme Inhibition; Escherichia Coli; Fruit (Structure); Ic50; Juniperus; Juniperus Communis Var. Saxatilis; Juniperus Oxycedrus Subsp. Oxycedrus; Limit Of Detection; Limit Of Quantitation; Liquid Chromatography-Mass Spectrometry; Mass Spectrometry; Minimum Inhibitory Concentration; Nonhuman; Proteus Mirabilis; Prunus; Prunus Cerasifera; Prunus Spinosa; Pseudomonas Aeruginosa; Qualitative Analysis; Quantitative Analysis; Salmonella Enterica; Secondary Metabolism; Staphylococcus Aureus
Kaynak
Ankara Universitesi Eczacilik Fakultesi Dergisi
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
47
Sayı
2
