Anti-apoptotic effects of curcumin on cadmium-induced apoptosis in rat testes

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dc.authoridOZTURK, Samil/0000-0002-9435-8139
dc.authorwosidAktas, Cevat/D-8468-2011
dc.authorwosidOZTURK, Samil/Q-4515-2019
dc.contributor.authorAktas, Cevat
dc.contributor.authorKanter, Mehmet
dc.contributor.authorErboga, Mustafa
dc.contributor.authorOzturk, Samil
dc.date.accessioned2024-06-12T10:55:28Z
dc.date.available2024-06-12T10:55:28Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCadmium (Cd) is one of the environmental pollutants affecting various tissues and organs including testis. The aim of this study was to investigate the anti-apoptotic effects of curcumin (Cur) on Cd-induced apoptosis in rat testes. The rats were randomly allotted into one of three experimental groups: control, Cd treated and Cd treated with Cur; each group contained 10 animals. The control group received 2 ml/day of dimethyl sulfoxide (DMSO). To induce toxicity, Cd (1 mg/kg body weight) was dissolved in normal saline and subcutaneously injected into rats for 4 weeks. The rats in Cur-treated group was given a daily dose of 100 mg/kg of Cur for 4 weeks. To date, no examinations of the anti-apoptotic properties of Cur on Cd-induced apoptosis in rat testes have been reported. The mean seminiferous tubule diameter, mean testicular biopsy score values and serum testosterone levels were significantly decreased in Cd-treated groups were compared to the control group. Furthermore, the Cur-treated animals showed an improved histological appearance and serum testosterone levels in Cd-treated group. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end-labeling in testis tissues of the Cd-treated group with Cur therapy. The present study showed that Cur treatment protected testes against toxic effects of Cd. We believe that further preclinical research into the utility of Cur may indicate its usefulness as a potential treatment on the spermatogenesis after testicular injury caused by Cd-treated rats.en_US
dc.identifier.doi10.1177/0748233711407242
dc.identifier.endpage130en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue2en_US
dc.identifier.pmid21632575en_US
dc.identifier.scopus2-s2.0-84859018306en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage122en_US
dc.identifier.urihttps://doi.org/10.1177/0748233711407242
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19433
dc.identifier.volume28en_US
dc.identifier.wosWOS:000300222800004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology And Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCadmiumen_US
dc.subjectCurcuminen_US
dc.subjectTUNELen_US
dc.subjectTestesen_US
dc.subjectTestosteroneen_US
dc.subjectInduced Lipid-Peroxidationen_US
dc.subjectSprague-Dawley Ratsen_US
dc.subjectGerm-Cell Apoptosisen_US
dc.subjectLeydig-Cellsen_US
dc.subjectStrand Breaksen_US
dc.subjectShort-Termen_US
dc.subjectZincen_US
dc.subjectToxicityen_US
dc.subjectProteinen_US
dc.subjectDamageen_US
dc.titleAnti-apoptotic effects of curcumin on cadmium-induced apoptosis in rat testesen_US
dc.typeArticleen_US

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