Ovulatuar ve anovulatuar polikistik over sendromlu hastalarda Prostat Spesifik Antijen ve serbest Prostat Spesifik Antijen'nın tanısal değeri
Küçük Resim Yok
Tarih
2009
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Trakya Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Ovulatuar polikistik over sendromlu hastaların tanısı zordur. Çalışmamızda ovulatuar ve anovulatuar hastalarda prostat spesifik antijen ve serbest prostat spesifik antijenin tanısal değerini ölçtük. Hem ovulatuar hem anovulatuar grupta androjenik hormonlar, prostat spesifik antijen ve serbest prostat spesifik antijen kontrol grubuna göre anlamlı olarak daha yüksek düzeylerdeydi (p<0.05). Ovulatuar ve anovulatuar grupta bu değerler arasında anlamlı farklılık yoktu. Hasta grubunda prostat spesifik antijen ve serbest prostat spesifik antijenin, total testosteron ve androstenedion gibi androjenik hormonlarla pozitif yönde korelasyon gösterdiği bulundu.Polikistik over sendromu grubunu anovulatuar (n=27, grup A) ve ovulatuar (n=20, grup B) olarak iki gruba ayırdık. Bulduğumuz prostat spesifik antijen ve serbest prostat spesifik antijenin ?cut-off? değerlerini; sendromun tanısındaki sensitivite, spesivite, pozitif ve negatif prediktif değerler, tanısal doğruluk açısından değerlendirdik. Prostat spesifik antijen ve serbest prostat spesifik antijenin sendromun tanısındaki ?cut-off? değerleri; prostat spesifik antijenin >10 pg/mL, serbest prostat spesifik antijenin >3pg/mL olarak belirlendi. Anovulatuar ve ovulatuar hastalarda prostat spesifik antijen ve serbest prostat spesifik antijenin tanısal performansları değerlendirildi.Anovulatuar hasta grubunda prostat spesifik antijenin >10 pg/mL ?cut-off? değeri için sensitivite %100, spesivite %100, tanısal doğruluk %100, pozitif prediktif değer %100, negatif prediktif değer %100; serbest prostat spesifik antijenin >3 pg/mL ?cut-off? değeri için sensitivite %96.3, spesivite %97.2, tanısal doğruluk %96.82, pozitif prediktif değer %96.3, negatif prediktif değer %97.2 olarak saptandı.Ovulatuar hasta grubunda prostat spesifik antijenin >10 pg/mL ?cut-off? değeri için sensitivite %85, spesivite %100, tanısal doğruluk %94.64, pozitif prediktif değer %100, negatif prediktif değer %92.3; serbest prostat spesifik antijenin >3 pg/mL ?cut-off? değeri için sensitivite %90, spesivite %97.1, tanısal doğruluk %96.4, pozitif prediktif değer %96.3, negatif prediktif değer %97.2 olarak saptandıBu verilerin ışığında prostat spesifik antijen ve prostat spesifik antijenin ovulatuar ve anovulatuar polikistik over sendromu tanısında faydalı biyokimyasal belirteçler olabileceği sonucuna varıldı.
Diagnosis of ovulatory polycystic ovary syndrome is very difficult. We assessed the diagnostic value of prostate-specific antigen and free prostate-specific antigen in women with ovulatory or anovulatory patients. Prostate-specific antigen, free prostate-specific antigen and circulating androgens levels were significantly elevated in the patients than control group (p<0.05). There was no significant difference between ovulatory and nonovulatory group. Positive correlations were found in the levels prostate-specific antigen and free prostate-specific antigen between circulating androgens as total testosterone and androstenedione.The patients was divided into two subgroups as anovulatory (n = 27, group A) and ovulatory group (n = 20, group B). A cut-off level of prostate-specific antigen and free prostate-specific antigen was established for the sensitivity, specificity, positive likelihood ratio, area under curve, diagnostic accuracy, and positive and negative predictive values of diagnosis of polycystic ovary syndrome. Cut-off levels of prostate-specific antigen and free prostate specific antigen were found respectively >10 pg/mL and >3 pg/mL. Diagnostic value of prostate-specific antigen and free prostate specific antigen were evaluated in women with ovulatory and anovulatory patients.In anovulatory group, a prostate specific antigen level of greater than 10 pg/ml yielded a sensitivity of 100%, a specificity of 100%, and a diagnostic accuracy of 100%, with a positive predictive value of 100% and a negative predictive value of 100%. An free prostate specific antigen level of greater than 3 pg/ml yielded a sensitivity of 96.3%, a specificity of 97.2%, and a diagnostic accuracy of 96.8%, with a positive predictive value of 96.3% and a negative predictive value of 97.2%. In ovulatory group, a prostate specific antigen level of greater than 10 pg/ml yielded a sensitivity of 85%, a specificity of 100%, and a diagnostic accuracy of 94.6%, with a positive predictive value of 100% and a negative predictive value of 92.3%. An free prostate specific antigen level of greater than 3 pg/ml yielded a sensitivity of 90%, a specificity of 97.1%, and a diagnostic accuracy of 96.4%, with a positive predictive value of 96.3% and a negative predictive value of 97.2%.We concluded that prostate-specific antigen and free prostate-specific antigen could be useful biochemical marker in the diagnosis of anovulatory and ovulatory polycystic ovary syndrome according to our data outcomes.
Diagnosis of ovulatory polycystic ovary syndrome is very difficult. We assessed the diagnostic value of prostate-specific antigen and free prostate-specific antigen in women with ovulatory or anovulatory patients. Prostate-specific antigen, free prostate-specific antigen and circulating androgens levels were significantly elevated in the patients than control group (p<0.05). There was no significant difference between ovulatory and nonovulatory group. Positive correlations were found in the levels prostate-specific antigen and free prostate-specific antigen between circulating androgens as total testosterone and androstenedione.The patients was divided into two subgroups as anovulatory (n = 27, group A) and ovulatory group (n = 20, group B). A cut-off level of prostate-specific antigen and free prostate-specific antigen was established for the sensitivity, specificity, positive likelihood ratio, area under curve, diagnostic accuracy, and positive and negative predictive values of diagnosis of polycystic ovary syndrome. Cut-off levels of prostate-specific antigen and free prostate specific antigen were found respectively >10 pg/mL and >3 pg/mL. Diagnostic value of prostate-specific antigen and free prostate specific antigen were evaluated in women with ovulatory and anovulatory patients.In anovulatory group, a prostate specific antigen level of greater than 10 pg/ml yielded a sensitivity of 100%, a specificity of 100%, and a diagnostic accuracy of 100%, with a positive predictive value of 100% and a negative predictive value of 100%. An free prostate specific antigen level of greater than 3 pg/ml yielded a sensitivity of 96.3%, a specificity of 97.2%, and a diagnostic accuracy of 96.8%, with a positive predictive value of 96.3% and a negative predictive value of 97.2%. In ovulatory group, a prostate specific antigen level of greater than 10 pg/ml yielded a sensitivity of 85%, a specificity of 100%, and a diagnostic accuracy of 94.6%, with a positive predictive value of 100% and a negative predictive value of 92.3%. An free prostate specific antigen level of greater than 3 pg/ml yielded a sensitivity of 90%, a specificity of 97.1%, and a diagnostic accuracy of 96.4%, with a positive predictive value of 96.3% and a negative predictive value of 97.2%.We concluded that prostate-specific antigen and free prostate-specific antigen could be useful biochemical marker in the diagnosis of anovulatory and ovulatory polycystic ovary syndrome according to our data outcomes.
Açıklama
Tıpta Uzmanlık
Anahtar Kelimeler
Kadın Hastalıkları ve Doğum, Obstetrics and Gynecology
