Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats

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dc.authoridTezel, Ahmet/0000-0002-3054-475X
dc.authoridUmit, Hasan/0000-0002-3651-4180
dc.authorwosidUmit, Hasan/T-6236-2019
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.contributor.authorSoylu, Ali Riza
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorBasaran, Umit Nusret
dc.contributor.authorAltaner, Semsi
dc.contributor.authorTarcin, Orhan
dc.contributor.authorGedik, Nursal
dc.contributor.authorUmit, Hasan
dc.date.accessioned2024-06-12T11:03:08Z
dc.date.available2024-06-12T11:03:08Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAIM: To investigate whether antioxidants vitamin E and C can retard development of hepatic fibrosis in the biliary-obstructed rats. METHODS: Fifty Wistar albino rats were randomly assigned to 5 groups (10 rats in each). Bile duct was ligated in 40 rats and they were treated as follows: group vitC, vitamin C 10 mg/kg sc daily; group vitE, vitamin E 15 mg/kg sc daily; group vitEC, both of the vitamins; bile duct-ligated (BDL, control) group, physiological saline sc. The fifth group was assigned to sham operation. At the end of fourth week, the rats were decapitated, and hepatic tissue biochemical collagen content and collagen surface area were measured. Hepatic tissue specimens were histopathologically evaluated according to Scheuer system. Serum hyaluronate levels were measured by ELISA method. RESULTS: Despite being higher than sham group, hepatic collagen level was significantly decreased in each of the vitC, vitE and vitEC groups (32.7 +/- 1.2, 33.8 +/- 2.9, 36.7 +/- 0.5 mu g collagen/mg protein, respectively) compared to BDL (48.3 +/- 0.6 mg collagen/g protein) (P < 0.001 for each vitamin group). Each isolated vitamin C, isolated vitamin E and combined vitamin E/C supplementation prevented the increase in hepatic collagen surface density (7.0% +/- 1.1%, 6.2% +/- 1.7%, 12.3% 2.0%, respectively) compared to BDL (17.4% +/- 5.6%) (P < 0.05 for each). The same beneficial effect of vitamin C, vitamin E and combined vitamin E/C treatment was also observed on the decrease of serum hyaluronate levels compared to BDL group (P < 0.001). The relative liver and spleen weights, serum transaminases, cholestatic enzymes, bilirubins and histopathological inflammation scores were not different between the antioxidant treatment groups and the control. However, fibrosis staging scores were obviously reduced only in the vitamin E/C combination group (vit EC: 2.4 +/- 0.8 vs BDL: 3.1 +/- 0.7; P < 0.05). CONCLUSION: Each antioxidant vitamin E, vitamin C and their combination retard hepatic fibrosis in biliary-obstructed rats. Oxidative stress may play a role in the pathogenesis of hepatic fibrosis in secondary biliary cirrhosis. (C) 2006 The WJG Press. All rights reserved.en_US
dc.identifier.doi10.3748/wjg.v12.i42.6835
dc.identifier.endpage6841en_US
dc.identifier.issn1007-9327
dc.identifier.issue42en_US
dc.identifier.pmid17106933en_US
dc.identifier.scopus2-s2.0-33751366650en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage6835en_US
dc.identifier.urihttps://doi.org/10.3748/wjg.v12.i42.6835
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21546
dc.identifier.volume12en_US
dc.identifier.wosWOS:000242105400015en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW J G Pressen_US
dc.relation.ispartofWorld Journal Of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatic Fibrosisen_US
dc.subjectBiliary Obstructionen_US
dc.subjectCollagenen_US
dc.subjectVitamin Een_US
dc.subjectVitamin Cen_US
dc.subjectAlpha-1(I) Gene-Expressionen_US
dc.subjectBile-Duct Obstructionen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectOxidative-Stressen_US
dc.subjectLiver Fibrosisen_US
dc.subjectTissue-Injuryen_US
dc.subjectLigated Ratsen_US
dc.subjectCollagenen_US
dc.subjectSupplementationen_US
dc.subjectDamageen_US
dc.titleAntioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed ratsen_US
dc.typeArticleen_US

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