Utility of 99mTc dextran scintigraphy in diabetic patients with suspected osteomyelitis of the foot

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dc.contributor.authorSarikaya, A
dc.contributor.authorAygit, AC
dc.contributor.authorPekindil, G
dc.date.accessioned2024-06-12T10:59:27Z
dc.date.available2024-06-12T10:59:27Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: Osteomyelitis of the foot is a frequent complication of diabetes mellitus and its diagnosis is often difficult. The goal of this study was to demonstrate the utility of Tc-99m dextran scintigraphy in suspected diabetic foot infections. Materials and Methods: Twenty-six patients (20 males, 6 females, age range 18-80 years) with diabetes mellitus who had a total of 36 foot ulcers or necrosis were studied. All the patients underwent both three phase bone scan and Tc-99m dextran scintigraphy. Final diagnosis was based upon either pathologic examination or clinical follow-up at least four months. Results: On bone scan increased uptake was seen in 55 sites, and among these there were 11 lesions of proven osteomyelitis. There were 11 true-positive, 0 false negative, 0 true negative and 44 false positive results for bone scan. The sensitivity, specificity and accuracy of bone scan were 100%, 0% and 20%, respectively. With regard to Tc-99m dextran scan, nine lesions produced true-positive results with two lesions indicating false negatives resulting in a sensitivity of 82%. Thirty-six true negative and eight false positive results produced a specificity of 82%, and an accuracy 82% from Tc-99m dextran studies was obtained. Eight false-positive results were possibly due to neuroarthropathy, pressure points and deep penetrating ulcers. A patient with one false-negative result had angiopathy while other had neither neuropathy nor angiopathy. Conclusions: According to these results, Tc-99m dextran scintigraphy seems to be a sensitive and specific diagnostic method, and because of its advantages over other radiopharmaceuticals (shorter preparation time, highly stability in vivolin vitro, early diagnostic imaging and low cost), it may be a radiopharmaceutical of choice for diagnosing in diabetic foot infections.en_US
dc.identifier.doi10.1007/BF02984973
dc.identifier.endpage676en_US
dc.identifier.issn0914-7187
dc.identifier.issn1864-6433
dc.identifier.issue8en_US
dc.identifier.pmid14971609en_US
dc.identifier.scopus2-s2.0-1042279673en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage669en_US
dc.identifier.urihttps://doi.org/10.1007/BF02984973
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20453
dc.identifier.volume17en_US
dc.identifier.wosWOS:000188593600007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAnnals Of Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetic Footen_US
dc.subjectInfectionen_US
dc.subjectScintigraphyen_US
dc.subjectTc-99m Dextranen_US
dc.subjectLeukocyte Scintigraphyen_US
dc.subjectImmunoglobulin-Gen_US
dc.subjectInfectionsen_US
dc.subjectDiagnosisen_US
dc.subjectBoneen_US
dc.subjectLymphoscintigraphyen_US
dc.subjectInflammationen_US
dc.subjectJointen_US
dc.titleUtility of 99mTc dextran scintigraphy in diabetic patients with suspected osteomyelitis of the footen_US
dc.typeArticleen_US

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