Analysis of the anti-allodynic effects of combination of a synthetic cannabinoid and a selective noradrenaline re-uptake inhibitor in nerve injury-induced neuropathic mice

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dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorGunduz, O.
dc.contributor.authorTopuz, R. D.
dc.contributor.authorKaradag, C. H.
dc.contributor.authorUlugol, A.
dc.date.accessioned2024-06-12T11:19:46Z
dc.date.available2024-06-12T11:19:46Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackgroundCombining drugs not only reduces specific adverse effects of each of the drug at a higher dose but also may lead to enhanced efficacy. Tapentadol is a recently discovered analgesic possessing -opioid receptor agonism and noradrenaline re-uptake inhibition in a single molecule. Taking into consideration, the pharmacological similarities between opioids and cannabinoids, we assumed that combination of cannabinoids with noradrenaline re-uptake inhibitors might also be effective. We therefore aimed to determine whether combining 1:1, 1:3 and 3:1 fixed ratios of the synthetic cannabinoid WIN 55,212-2 and the selective noradrenaline re-uptake inhibitor maprotiline exert anti-allodynic synergy on nerve-injured neuropathic mice. MethodsPartial tight ligation of the sciatic nerve was made in mice; on pre-operative and post-operative 15 days basal mechanical allodynia, cold allodynia and motor function were assessed using von Frey filaments, hot/cold plate and rota rod apparatus. ResultsMechanical and cold allodynia developed in all groups on post-operative 15 days. Development of cold allodynia was statistically significant in all groups (p<0.05); therefore, cold allodynia was used in combination studies. As shown by isobolographic analysis, interactions of 1:1 and 3:1 ratios of WIN 55,212-2:maprotiline combinations were supra-additive, whereas 1:3 ratio was sub-additive. ConclusionsOverall, our data suggest that combination of a cannabinoid with a selective noradrenaline re-uptake inhibitor may offer a beneficial treatment option for neuropathic pain.en_US
dc.description.sponsorshipTUBITAK [113S162]en_US
dc.description.sponsorshipThis work was supported by a grant from TUBITAK (113S162).en_US
dc.identifier.doi10.1002/ejp.752
dc.identifier.endpage471en_US
dc.identifier.issn1090-3801
dc.identifier.issn1532-2149
dc.identifier.issue3en_US
dc.identifier.pmid26206340en_US
dc.identifier.scopus2-s2.0-84958839704en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage465en_US
dc.identifier.urihttps://doi.org/10.1002/ejp.752
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25338
dc.identifier.volume20en_US
dc.identifier.wosWOS:000370446500014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofEuropean Journal Of Painen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRat Formalin Testen_US
dc.subjectChronic Painen_US
dc.subjectTactile Allodyniaen_US
dc.subjectReceptor Agonisten_US
dc.subjectWin 55,212-2en_US
dc.subjectTapentadolen_US
dc.subjectToleranceen_US
dc.subjectAntinociceptionen_US
dc.subjectWin-55,212-2en_US
dc.subjectAnalgesicsen_US
dc.titleAnalysis of the anti-allodynic effects of combination of a synthetic cannabinoid and a selective noradrenaline re-uptake inhibitor in nerve injury-induced neuropathic miceen_US
dc.typeArticleen_US

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