Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats

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dc.contributor.authorKanter, Mehmet
dc.contributor.authorCoskun, Omer
dc.contributor.authorBudancamanak, Mustafa
dc.date.accessioned2024-06-12T10:55:58Z
dc.date.available2024-06-12T10:55:58Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAIM: To investigate the effects of Nigella sativa L (NS) and Urtica dioica L (UD) on lipid peroxidation, antioxidant enzyme systems and liver enzymes in CCl4-treated rats. METHODS: Fifty-six healthy male Wistar albino rats were used in this study. The rats were randomly allotted into one of the four experimental groups: A (CCl4-only treated), B (CCl4+UD treated), C (CCl4+NS treated) and D (CCl4+UD+NS treated), each containing 14 animals. All groups received CCl4 (0.8 mL/kg of body weight, sc, twice a week for 60 d). In addition, B, C and D groups also received daily i.p. injections of 0.2 mL/kg NS or/and 2 mL/kg UD oils for 60 d. Group A, on the other hand, received only 2 mL/kg normal saline solution for 60 d. Blood samples for the biochemical analysis were taken by cardiac puncture from randomly chosen-seven rats in each treatment group at beginning and on the 60th d of the experiment. RESULTS: The CCl4 treatment for 60 d increased the lipid peroxidation and liver enzymes, and also decreased the antioxidant enzyme levels. NS or UD treatment (alone or combination) for 60 d decreased the elevated lipid peroxidation and liver enzyme levels and also increased the reduced antioxidant enzyme levels. The weight of rats decreased in group A, and increased in groups B, C and D. CONCLUSION: NS and UD decrease the lipid peroxidation and liver enzymes, and increase the antioxidant defense system activity in the CCl4-treated rats. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.3748/wjg.v11.i42.6684
dc.identifier.endpage6688en_US
dc.identifier.issn1007-9327
dc.identifier.issn2219-2840
dc.identifier.issue42en_US
dc.identifier.pmid16425366en_US
dc.identifier.scopus2-s2.0-30444452089en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage6684en_US
dc.identifier.urihttps://doi.org/10.3748/wjg.v11.i42.6684
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19618
dc.identifier.volume11en_US
dc.identifier.wosWOS:000208224700021en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBaishideng Publishing Group Incen_US
dc.relation.ispartofWorld Journal Of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCcl4en_US
dc.subjectNigella Sativa L.en_US
dc.subjectUrtica Dioica L.en_US
dc.subjectLipid Peroxidationen_US
dc.subjectAntioxidant Enzymesen_US
dc.subjectRaten_US
dc.titleHepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated ratsen_US
dc.typeArticleen_US

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