Effects of natural waste on in vitro oxidative DNA damage

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dc.authoridDanjolli-Hashani, Dua/0000-0002-7377-6518
dc.contributor.authorDanjolli-Hashani, Dua
dc.contributor.authorIsbilir, Sebnem Selen
dc.date.accessioned2024-06-12T11:11:53Z
dc.date.available2024-06-12T11:11:53Z
dc.date.issued2024
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn this study, the effects of natural waste products such as extracts from C. coggygria leaves and Punica granatum L. peels were investigated against oxidative DNA damage induced by Fenton reaction. 8-OH-2'dG as a general marker of DNA damage on thymus DNA, and the bioactive compounds of extracts were measured by LC-MS/MS. Our results had shown that ethanol extracts of C. coggygria leaf and Punica granatum L. peel had a protective effect on oxidative damaged DNA. It was determined that the bioactive compounds of C. coggygria leaves (gallic acid, protocatechuic acid, myricetin, syringic acid and ethyl gallate as a major compounds) and Punica granatum L. peel (ellagic acid, abscisic acid, ethyl gallate, phlorizin, gallic acid, myricetin as major compounds) may have an important role in the protective effect against oxidative DNA damage. Therefore, Cotinus coggygria leaves and Punica granatum L. peel may have potential use in medicine or cosmetic fields.en_US
dc.description.sponsorshipTechnology Research Development Application and Research Center (TUTAGEM); Technology Research Development Application and Research Center (TUTAGEM)en_US
dc.description.sponsorshipThe authors would like to express their gratitude to the Technology Research Development Application and Research Center (TUTAGEM) for providing support with the LC-MS/MS analysis. The taxonomic identify of the plant was provided by Dr. Necmettin Guler, for which the authors are appreciative. Also, the authors would like to express our gratitude to the Bat & imath; Akdeniz Agricultural Research Institute (BATEM-Antalya) for supplying the pomegranates used in this study.en_US
dc.identifier.doi10.1080/14786419.2024.2340044
dc.identifier.issn1478-6419
dc.identifier.issn1478-6427
dc.identifier.pmid38608249en_US
dc.identifier.scopus2-s2.0-85190138754en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/14786419.2024.2340044
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22971
dc.identifier.wosWOS:001201773400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNatural Product Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxidative DNA Damageen_US
dc.subjectCotinus Coggygria Leavesen_US
dc.subjectPunica Granatum L. Peelen_US
dc.subject8-OH-2'dgen_US
dc.subjectLC-MS/MSen_US
dc.subjectCotinus-Coggygria Scop.en_US
dc.subjectAntioxidant Activityen_US
dc.subjectExtracten_US
dc.subjectPomegranateen_US
dc.subjectAciden_US
dc.subjectStressen_US
dc.subjectPeelen_US
dc.titleEffects of natural waste on in vitro oxidative DNA damageen_US
dc.typeArticleen_US

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