Exchange transfusion for neonatal hyperbilirubinemia: A multicenter, prospective study of Turkish Neonatal Society

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dc.authoridOkulu, Emel/0000-0002-1101-3355;
dc.authorwosidErtugrul, Sabahattin/JUU-2567-2023
dc.authorwosidOkulu, Emel/AAH-8855-2020
dc.authorwosidZoglu, Aysegul/HJP-7031-2023
dc.authorwosidYasa, Beril/JFA-5398-2023
dc.contributor.authorOkulu, Emel
dc.contributor.authorErdeve, Omer
dc.contributor.authorTuncer, Oguz
dc.contributor.authorErtugrul, Sabahattin
dc.contributor.authorOzdemir, Hulya
dc.contributor.authorCiftdemir, Nukhet Aladag
dc.contributor.authorZenciroglu, Aysegul
dc.date.accessioned2024-06-12T10:58:13Z
dc.date.available2024-06-12T10:58:13Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The frequency of neonatal exchange transfusion has declined in recent years, but is still performed in many countries. The procedure is associated with complications. The aim of the study was to determine the clinical features and etiologies of infants with hyperbilirubinemia who underwent exchange transfusion and evaluate the adverse events and clinical outcomes. Material and Methods: We performed a secondary analysis of the multicenter Turkish Neonatal Jaundice Online Registry data. Otherwise healthy newborns born >= 35 weeks of gestation who were hospitalized for jaundice and underwent exchange transfusion were included. Results: One-hundred thirty-two patients with a mean serum bilirubin level on admission of 24.9 +/- 9.1 mg/dL were enrolled in the study. The most common cause for exchange transfusion was hemolytic jaundice (63.6%), followed by lack of proper feeding (12.9%). It was found that the infants with lack of proper feeding were discharged earlier from the maternity ward (p=0.02), but they were admitted to hospital later (p<0.001) with a higher bilirubin level (p=0.001), and geater weight loss (p=0.04). The reported rate of adverse events associated with exchange transfusion was 11.4%. The most common complication was thrombocytopenia (40%). None of the infants died during the procedure. Acute bilirubin encephalopathy was reported in 13 (9.8%) patients. Conclusion: Severe hyperbilirubinemia requiring exchange transfusion and acute bilirubin encephalopathy are still challenging problems in neonatal periodin our country. The policies including blood group analysis of pregnant women, programs informing parents about breast-feeding and jaundice, and monitoring bilirubin levels of high-risk newborns should be developed to reduce the necessitating for exchange transfusion and to avoid related complications.en_US
dc.description.sponsorshipTurkish Neonatal Societyen_US
dc.description.sponsorshipWe thank to Turkish Neonatal Society for funding the project, to all collaborator NICUs and the investigators, as the members of the Exchange Transfusion Study Group*. The following investigators are the members of the Turkish Neonatal Society Exchange Transfusion Study Group: Saadet Arsan (Ankara University Faculty of Medicine, Ankara), Deniz Hanta (Adana Gynecology and Obstetrics and Children's Hospital, Adana), Ramazan Ozdemir (Inonu University Faculty of Medicine, Malatya), Beril Yasa (Istanbul University Faculty of Medicine, Istanbul), Bilge Tanyeri Bayraktar (Bezmialem University Faculty of Medicine, Istanbul), Gokhan Buyukkale (Kanuni Training and Research Hospital, Istanbul), Berna Hekimoglu (Kanuni Training and Research Hospital, Trabzon), Nilufer Guzoglu (Kirikkale University Faculty of Medicine, Kirikkale), Ayse Engin Arisoy (Kocaeli University Faculty of Medicine, Kocaeli), Elif Ozyazici (Ondokuz Mayis University Faculty of Medicine, Samsun), Ozge Aydemir (Osmangazi University Faculty of Medicine, Eskisehir), Akan Yaman (Sanliurfa Gynecology and Obstetrics Hospital, Sanliurfa), Hilal Ozkan (Uludag University Faculty of Medicine, Bursa), Leyla Bilgin (Umraniye Research and Training Hospital, Istanbul), Evrim Alyamac Dizdar (Zekai Tahir Burak Maternity Teaching Hospital, Ankara).en_US
dc.identifier.doi10.14744/TurkPediatriArs.2020.65983
dc.identifier.endpage126en_US
dc.identifier.issn2757-6256
dc.identifier.issue2en_US
dc.identifier.pmid34286320en_US
dc.identifier.scopus2-s2.0-85118905003en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage121en_US
dc.identifier.trdizinid445503en_US
dc.identifier.urihttps://doi.org/10.14744/TurkPediatriArs.2020.65983
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/445503
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19984
dc.identifier.volume56en_US
dc.identifier.wosWOS:000624295100005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Archives Of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectComplicationen_US
dc.subjectExchange Transfusionen_US
dc.subjectHyperbilirubinemiaen_US
dc.subjectNewbornen_US
dc.subjectBreast-Feeding Initiationen_US
dc.subjectHealthy Termen_US
dc.subjectWhole-Blooden_US
dc.subjectManagementen_US
dc.subjectInfantsen_US
dc.subjectKernicterusen_US
dc.subjectExperienceen_US
dc.subjectMorbidityen_US
dc.subjectBilirubinen_US
dc.subjectDeliveryen_US
dc.titleExchange transfusion for neonatal hyperbilirubinemia: A multicenter, prospective study of Turkish Neonatal Societyen_US
dc.typeArticleen_US

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