In vivo effects of curcumin and deferoxamine in experimental endometriosis

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dc.authoridUlucam, Enis/0000-0002-4686-7350
dc.authoridUz, Yesim/0000-0002-0381-4590
dc.authorwosidUlucam, Enis/AAG-9204-2019
dc.authorwosidUluçam, Enis/HQZ-3831-2023
dc.authorwosidYılmaz, Ali/KLZ-9798-2024
dc.contributor.authorKizilay, Gulnur
dc.contributor.authorUz, Yesim Hulya
dc.contributor.authorSeren, Gulay
dc.contributor.authorUlucam, Enis
dc.contributor.authorYilmaz, Ali
dc.contributor.authorCukur, Ziya
dc.contributor.authorKayisli, Umit Ali
dc.date.accessioned2024-06-12T10:58:58Z
dc.date.available2024-06-12T10:58:58Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground. Endometriosis is one of the most common chronic gynecological diseases. Objectives. The aim of the study was to examine the effects of curcumin and/or deferoxamine on cell proliferation in a rat model of endometriosis. Material and methods. Thirty female 12-week-old albino Wistar rats, weighing 200-250 g, were used in this study. All the rats underwent ovariectomy and 0.1-mg beta-estradiol 17-valerate pellets were placed intraperitoneally. An experimental model of endometriosis was created in all the animals. To create the experimental model, an approximately 1-cm long section of the uterus was taken, primarily from the right horn of the uterus. Autologous fragments were then placed between the peritoneum and muscle. The animals were divided into 3 groups: Group A, treated only with the vehicle used for curcumin and deferoxamine; group B, treated with curcumin (100 mg/kg body weight); and group C, treated with deferoxamine + curcumin (100 mg/kg body weight). After biopsy samples were obtained, the sections were stained with hematoxylin and eosin. Immunostaining for cytokeratin-7 and proliferating cell nuclear antigen (PCNA) was performed. Blood iron levels were measured using a Perkin Elmer AAnalyst 800 Atomic Absorption Spectrophotometer. Results. The endometrial implant size increased in Group A, but treatment with curcumin (p = 0.01) and deferoxamine + curcumin (p = 0.007) reduced the implant size. In ectopic endometrial epithelial cells, there were significant decreases in PCNA immunoreactivity between groups A and B (p = 0.044) and between groups A and C (p = 0.033). Conclusions. Treatment with curcumin alone and/or in combination with deferoxamine contributed to a reduction in implant size and cell proliferation in a rat endometriosis model. Iron-chelating agents may act in the same manner when used in women with endometriosis; however, further studies from different perspectives are still needed.en_US
dc.description.sponsorshipTrakya University Research Center, Edirne, Turkeyen_US
dc.description.sponsorshipThis study was supported by Trakya University Research Center, Edirne, Turkey.en_US
dc.identifier.doi10.17219/acem/31186
dc.identifier.endpage213en_US
dc.identifier.issn1899-5276
dc.identifier.issn2451-2680
dc.identifier.issue2en_US
dc.identifier.pmid28791836en_US
dc.identifier.scopus2-s2.0-85018340638en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage207en_US
dc.identifier.urihttps://doi.org/10.17219/acem/31186
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20267
dc.identifier.volume26en_US
dc.identifier.wosWOS:000402469300003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWroclaw Medical Univen_US
dc.relation.ispartofAdvances In Clinical And Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCurcuminen_US
dc.subjectEndometriosisen_US
dc.subjectDeferoxamineen_US
dc.subjectPCNAen_US
dc.subjectIron Overloaden_US
dc.subjectLesionsen_US
dc.subjectCellsen_US
dc.subjectModelen_US
dc.subjectVascularizationen_US
dc.subjectInvolvementen_US
dc.subjectGrowthen_US
dc.subjectRatsen_US
dc.titleIn vivo effects of curcumin and deferoxamine in experimental endometriosisen_US
dc.typeArticleen_US

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