The incidence of recurrence and hypothyroidism after radioiodine treatment in patients with hyperthyroidism in Trakya, a mild iodine deficiency area, during the period 1991-2003

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dc.authoridCermik, Tevfik Fikret/0000-0001-7622-7277
dc.authoridDURMUS ALTUN, GULAY/0000-0002-1822-9386
dc.authorwosidCermik, Tevfik Fikret/A-9694-2018
dc.authorwosidDURMUS ALTUN, GULAY/S-6586-2016
dc.contributor.authorUstun, F
dc.contributor.authorYuksel, M
dc.contributor.authorDurmus-Altun, G
dc.contributor.authorKaya, M
dc.contributor.authorÇermik, TF
dc.contributor.authorSarikaya, A
dc.contributor.authorBerkarda, S
dc.date.accessioned2024-06-12T11:13:22Z
dc.date.available2024-06-12T11:13:22Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description5th International Congress of Nuclear Oncology/15th National Congress of Nuclear-Society-of-Nuclear-Medicine -- MAY 01-05, 2002 -- Kusadasi, TURKEYen_US
dc.description.abstractObjective: The purpose of this retrospective study was to evaluate the incidence of recurrence and the success of radioiodine treatment (RIT) in the Trakya region of Turkey, an area with mild iodine deficiency, and to compare the effect of dose regimen selection (fixed (FD) or calculated dose (CD)) on treatment success. Material and Methods: The study sample included 148 patients (40 male, median age 50) treated with radioiodine between the years 1991-2003. Patients were categorized into three diagnostic groups: Graves' disease (GD) (n = 65), solitary toxic adenoma (TA) (n = 29), and toxic multinodular hyperthyroidism (TMH) (n = 54), and each divided into two subgroups according to treatment method; the first group was treated with a FD of 370 MBq (10 mCi), and the second with CD. Results: The largest group was GD (44%), followed by TMH (36%). Median duration of follow-up was 28 months (range 6-147). FD was given to 52.7% of all patients and CD was given to 47.3%. There was a partial difference in the dose regimen between all groups, but did not reach statistically significant levels (FD vs. CD: 65%-35%; 38%-62%; 46%-54%; GD, TA, TMH respectively, p > 0.05). Total cure rate in FD and CD was 46 (59%) and 37 (52.9%), respectively. The rates of hypothyroidism for GD, TA, and TMH groups were 28 (43.1%), 6 (20.7%) and 16 (29.6%), respectively. The incidence of hypothyroidism did not vary significantly between any groups (p > 0.05). At the end of the follow-up period, a total of 104 patients (70.3%) were treated successfully. There was no significant difference in the cure rate between any groups (p > 0.05). Conclusions: The treatment success in all groups and subgroups did not differ significantly between FD and CD. Our lower cure rate than in previous studies may be related to iodine deficiency. Higher doses of radioiodine may be required to increase final treatment success in endemic goiter areas. If this true, dosimetry and calculated dose regimen would be required in all groups of patients instead of an FD concept. However, our findings should be verified in larger series of patients, with longer follow-up period, and urinary iodine concentration measurements.en_US
dc.description.sponsorshipNucl Soc Nucl Meden_US
dc.identifier.doi10.1007/BF02985126
dc.identifier.endpage742en_US
dc.identifier.issn0914-7187
dc.identifier.issn1864-6433
dc.identifier.issue8en_US
dc.identifier.pmid16445003en_US
dc.identifier.scopus2-s2.0-31744449996en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage737en_US
dc.identifier.urihttps://doi.org/10.1007/BF02985126
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23516
dc.identifier.volume19en_US
dc.identifier.wosWOS:000234309300016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAnnals Of Nuclear Medicineen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRadioiodine Therapyen_US
dc.subjectIodine Deficiencyen_US
dc.subjectGraves' Diseaseen_US
dc.subjectToxic Adenomaen_US
dc.subjectToxic Multinodular Goiteren_US
dc.subjectToxic Multinodular Goiteren_US
dc.subjectGraves-Diseaseen_US
dc.subjectThyroid-Disordersen_US
dc.subjectNodular Goiteren_US
dc.subjectTherapyen_US
dc.subjectThyrotoxicosisen_US
dc.subjectI-131en_US
dc.subjectPretreatmenten_US
dc.subjectManagementen_US
dc.subjectEfficacyen_US
dc.titleThe incidence of recurrence and hypothyroidism after radioiodine treatment in patients with hyperthyroidism in Trakya, a mild iodine deficiency area, during the period 1991-2003en_US
dc.typeConference Objecten_US

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