Blockade of cannabinoid CB1 and CB2 receptors does not prevent the antipruritic effect of systemic paracetamol

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dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.contributor.authorSaglam, Gulis
dc.contributor.authorGunduz, Ozgur
dc.contributor.authorUlugol, Ahmet
dc.date.accessioned2024-06-12T11:12:03Z
dc.date.available2024-06-12T11:12:03Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCannabinoid CB1 receptors have been shown to mediate the antinociceptive, but not the hypothermic, action of the worldwide used analgesic, paracetamol. Since itch and pain sensations share many similarities, the purpose of the present study was to investigate whether blockade of cannabinoid CB1 and CB2 receptors participates in the antipruritic activity of paracetamol in mice. Scratching behavior was induced by intradermal serotonin injection into the rostral part of the back of the mice. After serotonin administration, scratching of the injected site by the hind paws were videotaped and counted for 30 min. Serotonin-induced scratching behavior was attenuated with high-dose paracetamol (300 mg/kg). The CB1 receptor antagonist, AM-251 (1 mg/kg), and the CB2 receptor antagonist, SR-144528 (1 mg/kg), did not alter the anti-scratching behavioral effect of paracetamol. Our results indicate that, in contrast to its antinociceptive action, but similar to its hypothermic effect, cannabinoid receptors are not involved in the antipruritic activity of paracetamol.en_US
dc.description.sponsorshipTrakya University Research Council [TUBAP-2012/186]en_US
dc.description.sponsorshipThis work was supported by a grant from Trakya University Research Council (TUBAP-2012/186).en_US
dc.identifier.doi10.1007/s13760-013-0272-9
dc.identifier.endpage309en_US
dc.identifier.issn0300-9009
dc.identifier.issn2240-2993
dc.identifier.issue4en_US
dc.identifier.pmid24399199en_US
dc.identifier.scopus2-s2.0-84911861411en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage307en_US
dc.identifier.urihttps://doi.org/10.1007/s13760-013-0272-9
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23021
dc.identifier.volume114en_US
dc.identifier.wosWOS:000345405200011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofActa Neurologica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectParacetamolen_US
dc.subjectCannabinoid Receptorsen_US
dc.subjectAM-251en_US
dc.subjectSR-144528en_US
dc.subjectPruritusen_US
dc.subjectAntinociceptive Actionen_US
dc.subjectInduced Hypothermiaen_US
dc.subjectAcetaminophenen_US
dc.subjectPainen_US
dc.subjectInvolvementen_US
dc.subjectInsightsen_US
dc.subjectPruritusen_US
dc.subjectItchen_US
dc.titleBlockade of cannabinoid CB1 and CB2 receptors does not prevent the antipruritic effect of systemic paracetamolen_US
dc.typeArticleen_US

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