Evaluation of Pericardial Fluid C-Type Natriuretic Peptide Levels in Patients Undergoing Coronary Bypass Surgery

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dc.authoridKarahan, Oğuz/0000-0003-0044-9476
dc.authoridGUCLU, Orkut/0000-0001-6460-3175
dc.authoridYuksel, Volkan/0000-0001-9518-2588
dc.authoridHuseyin, Serhat/0000-0003-4118-040X
dc.authorwosidKarahan, Oğuz/E-8873-2010
dc.authorwosidGUCLU, Orkut/H-9993-2014
dc.contributor.authorGuclu, Orkut
dc.contributor.authorKarahan, Oguz
dc.contributor.authorKarabacak, Mustafa
dc.contributor.authorYuksel, Volkan
dc.contributor.authorHuseyin, Serhat
dc.contributor.authorMavitas, Binali
dc.date.accessioned2024-06-12T10:55:44Z
dc.date.available2024-06-12T10:55:44Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground Neurohumoral and hemodynamic mechanisms have an effect on cardiac activity. C-type natriuretic peptide (CNP) is accessible in the cardiovascular system. The aim of this study was to determine whether CNP concentrations in pericardial fluid and blood are related to cardiac dysfunction in patients undergoing coronary artery bypass graft surgery. Materials and Methods In this study, 40 patients undergoing coronary artery bypass grafting were enrolled. The patients were separated into two groups according to left ventricular (LV) ejection fraction (EF): group 1 contained 28 patients with normal LV systolic function (LVEF >= 50%) and group 2 contained 12 patients with impaired LV systolic function (LVEF < 45%). Plasma and pericardial fluid samples were acquired during surgery to measure CNP levels. Results In group 1, CNP levels were detected to be 0.46 +/- 0.10 ng/mL in plasma and 0.66 +/- 0.8 ng/mL in pericardial liquid. In group 2, these levels were 0.51 +/- 0.09 and 0.79 +/- 0.12 ng/mL, respectively. CNP levels were determined to be significantly higher in patients with low EF compared with those with normal EF in pericardial fluid concentrations (p = 0.013). Conclusions CNP level in pericardial fluid is a more sensitive and proper marker of LV dysfunction than CNP levels in plasma. To the best of our knowledge, this study is the first to examine pericardial fluid CNP levels in patients undergoing coronary artery bypass surgery. It may have a valuable role in organizing cardiac remodeling and hypertrophy.en_US
dc.identifier.doi10.1055/s-0036-1579626
dc.identifier.endpage314en_US
dc.identifier.issn0171-6425
dc.identifier.issn1439-1902
dc.identifier.issue4en_US
dc.identifier.pmid26962968en_US
dc.identifier.scopus2-s2.0-84961233461en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage311en_US
dc.identifier.urihttps://doi.org/10.1055/s-0036-1579626
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19537
dc.identifier.volume65en_US
dc.identifier.wosWOS:000402533800010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofThoracic And Cardiovascular Surgeonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiacen_US
dc.subjectCoronary Artery Bypass Graft Surgeryen_US
dc.subjectHeart Failureen_US
dc.subjectPlasmaen_US
dc.subjectHypertrophyen_US
dc.subjectExpressionen_US
dc.subjectArteriesen_US
dc.subjectSystemen_US
dc.subjectCnpen_US
dc.titleEvaluation of Pericardial Fluid C-Type Natriuretic Peptide Levels in Patients Undergoing Coronary Bypass Surgeryen_US
dc.typeArticleen_US

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