Combined Effectiveness of Honey and Immunonutrition on Bacterial Translocation Secondary to Obstructive Jaundice in Rats: Experimental Study

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dc.authoridIbis, Cem/0000-0002-5602-375X
dc.authoridSALT, OMER/0000-0002-5557-6627
dc.authorwosidIbis, Cem/AAE-3388-2020
dc.authorwosidGürcan, Şaban/D-2754-2017
dc.authorwosidOguz, Serhat/HKE-2793-2023
dc.contributor.authorOguz, Serhat
dc.contributor.authorSalt, Omer
dc.contributor.authorIbis, Abdil C.
dc.contributor.authorGurcan, Saban
dc.contributor.authorAlbayrak, Dogan
dc.contributor.authorYalta, Tulin
dc.contributor.authorSagiroglu, Tamer
dc.date.accessioned2024-06-12T10:54:10Z
dc.date.available2024-06-12T10:54:10Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Obstructive jaundice is a serious, life-threatening condition that can lead to death as a result of sepsis and multiorgan failure due to bacterial translocation. Treatment should be started as soon as possible after diagnosis. Material/Methods: Forty 24-week-old male Sprague Dawley rats, with an average weight of 250 g to 300 g, were included in this study. The rats were randomly placed into five groups, each group consisted of eight rats. The sham group underwent only common bile duct (CBD) dissection and no ligation was performed. CBD ligation was applied to the other groups. After the operation, one CBD group was fed with rat chow only, the others were fed with rat chow supplemented with honey, or immunonutrients, or honey plus immunonutrients. After 10 to 12 days, all rats were sacrificed; blood and tissue samples were collected for biochemical, microbiological, and histopathological evaluation. Results: In the groups that were fed with honey and immunonutrients, alanine aminotransferase (ALT) levels were de- creased significantly compared to the other groups. Statistically significant differences were detected in terms of bacterial translocation (BT) rates among liver and spleen samples, and laboratory values of serum, except for MLNs of the BDL+HI group, when compared to other groups. We found mean mucosal thickness of ileum samples have been improved notably in the BDL+HI group compared to the other groups, especially compared to the C/BDL group. Conclusions: Immunonutrition applied with honey had immunostimulant effects, decreased BT due to an additive effect, and had positive effects on intestinal mucosa.en_US
dc.identifier.doi10.12659/MSM.907977
dc.identifier.endpage3381en_US
dc.identifier.issn1643-3750
dc.identifier.pmid29786675en_US
dc.identifier.scopus2-s2.0-85048773725en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3374en_US
dc.identifier.urihttps://doi.org/10.12659/MSM.907977
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18951
dc.identifier.volume24en_US
dc.identifier.wosWOS:000432902700002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInt Scientific Information, Incen_US
dc.relation.ispartofMedical Science Monitoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBacterial Translocationen_US
dc.subjectHoneyen_US
dc.subjectIntestinesen_US
dc.subjectJaundice, Obstructiveen_US
dc.subjectIncreased Intestinal Permeabilityen_US
dc.subjectColony-Stimulating Factoren_US
dc.subjectGut Barrier Functionen_US
dc.subjectArginineen_US
dc.subjectLiveren_US
dc.subjectGlutamineen_US
dc.subjectPathophysiologyen_US
dc.subjectClearanceen_US
dc.subjectEnteritisen_US
dc.subjectAtrophyen_US
dc.titleCombined Effectiveness of Honey and Immunonutrition on Bacterial Translocation Secondary to Obstructive Jaundice in Rats: Experimental Studyen_US
dc.typeArticleen_US

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