Evaluation of SCUBE-1 and sCD40L biomarkers in patients with hypothyroidism due to Hashimoto's thyroiditis: a single-blind, controlled clinical study

Basit Öğe Kaydı
dc.authoridYILMAZ, Ibrahim/0000-0003-2003-6337
dc.authoridbilir, bulent/0000-0003-2112-4056
dc.authorwosidBaykız, Derya/ABD-7865-2020
dc.authorwosidBilir, Bülent/AAK-5656-2021
dc.authorwosidYILMAZ, Ibrahim/H-6199-2019
dc.contributor.authorBilir, B.
dc.contributor.authorSoysal-Atile, N.
dc.contributor.authorBilir, B. Ekiz
dc.contributor.authorYilmaz, I.
dc.contributor.authorBali, I.
dc.contributor.authorAltintas, N.
dc.contributor.authorBaykiz, D.
dc.date.accessioned2024-06-12T10:55:46Z
dc.date.available2024-06-12T10:55:46Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVE: This study was performed to investigate the levels of platelet activation marker SCUBE-1 and sCD40L which plays some role in the progression of atherosclerosis, in patients with hypothyroidism due to Hashimoto's thyroiditis. PATIENTS AND METHODS: The cohort of this study includes 90 patients and 35 healthy volunteers, who admitted to the internal medicine outpatient. Simultaneously in the same samples; SCUBE-1 and sCD40L measurements were accomplished by enzyme-linked immunosorbent assay (ELISA). The data obtained were analyzed statistically. RESULTS: Hypothyroidism due to Hashimoto's thyroiditis in comparison to the control group that includes healthy volunteers; SCUBE-1 and sCD40L, were increased. And these results were statistically significant (p < 0.05). CONCLUSIONS: SCUBE-1 and sCD40L levels were increased in Hashimoto's hypothyroidism patients. This may indicate an increased endothelial dysfunction, platelet activation and cardiovascular risk in hypothyroidism. SCUBE-1 and sCD40L may be helpful in cardiovascular risk assessment of hypothyroid patients.en_US
dc.identifier.endpage413en_US
dc.identifier.issn1128-3602
dc.identifier.issue3en_US
dc.identifier.pmid26914113en_US
dc.identifier.scopus2-s2.0-84987629335en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage407en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19552
dc.identifier.volume20en_US
dc.identifier.wosWOS:000371386300005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical And Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiovascular Risken_US
dc.subjectScd40len_US
dc.subjectHypothyroidismen_US
dc.subjectHashimoto's Thyroiditisen_US
dc.subjectSCUBE-1en_US
dc.subjectDomain-Containing Protein-1en_US
dc.subjectAcute Coronary Syndromesen_US
dc.subjectSubclinical Hypothyroidismen_US
dc.subjectHypertensive Patientsen_US
dc.subjectPlatelet Activationen_US
dc.subjectSerum-Levelsen_US
dc.subjectPeptideen_US
dc.subjectEndocanen_US
dc.subjectRisken_US
dc.subjectExpressionen_US
dc.titleEvaluation of SCUBE-1 and sCD40L biomarkers in patients with hypothyroidism due to Hashimoto's thyroiditis: a single-blind, controlled clinical studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu