Circulating microRNA expression profiles in ovarian cancer

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dc.authoridAYAZ, LOKMAN/0000-0002-2876-055X
dc.authorwosidTamer, Lulufer/AAG-5796-2021
dc.authorwosidYildirim, Hatice/O-7121-2016
dc.authorwosidAYAZ, LOKMAN/K-6716-2013
dc.contributor.authorAyaz, L.
dc.contributor.authorCayan, F.
dc.contributor.authorBalci, S.
dc.contributor.authorGorur, A.
dc.contributor.authorAkbayir, S.
dc.contributor.authorYaroglu, H. Yildirim
dc.contributor.authorUnal, N. Dogruer
dc.date.accessioned2024-06-12T11:08:30Z
dc.date.available2024-06-12T11:08:30Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMicroRNA (miRNA) is an abundant class of small non-coding RNAs that act as gene regulators. Recent studies have suggested that miRNA deregulation is associated with the initiation and progression of human cancer. However, information about ovarian cancer-related miRNA is mostly limited to tissue miRNA. The aim of this study was to find specific profiles of plasma-derived miRNAs of ovarian cancer. In this present study, the expression profiles of 740 miRNAs in plasma from 18 patients and 24 healthy women subjects were evaluated using microfluidic based multiplex qRT-PCR. Our results demonstrated that expression levels of eight miRNAs were significantly upregulated in patients with ovarian cancer when compared with a control group (p < 0.05). Expression levels of four miRNAs were found significantly downregulated in patients with ovarian cancer (p < 0.05). In addition, 10 miRNAs were expressed only in the ovarian cancer group and miR-138-5p of these miRNAs is ovarian specific. In conclusion, our study suggests that detecting these ovarian cancer specific miRNAs in plasma might serve as novel non-invasive biomarkers for ovarian cancer.en_US
dc.description.sponsorshipCukurova Development Agency (CKA), Mersin, Turkey [TR62-09-03]en_US
dc.description.sponsorshipThis study, which is the part of 'Establishment of Molecular Substructure Laboratory for Early Diagnosis of Cancer' (TR62-09-03) project, was supported by grants from Cukurova Development Agency (CKA), Mersin, Turkey.en_US
dc.identifier.doi10.3109/01443615.2014.919998
dc.identifier.endpage624en_US
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue7en_US
dc.identifier.pmid24911418en_US
dc.identifier.scopus2-s2.0-84925234812en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage620en_US
dc.identifier.urihttps://doi.org/10.3109/01443615.2014.919998
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22465
dc.identifier.volume34en_US
dc.identifier.wosWOS:000342229600016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Obstetrics And Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMicrornaen_US
dc.subjectMirnaen_US
dc.subjectOvarian Canceren_US
dc.subjectPlasma Mirnaen_US
dc.subjectRT-PCRen_US
dc.subjectIdentificationen_US
dc.subjectBiomarkersen_US
dc.subjectSignaturesen_US
dc.subjectPrognosisen_US
dc.subjectCarcinomaen_US
dc.subjectWomenen_US
dc.titleCirculating microRNA expression profiles in ovarian canceren_US
dc.typeArticleen_US

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