Synthesis, Cancer-Selective Antiproliferative and Apoptotic Effects of Some (±)-Naringenin Cycloaminoethyl Derivatives

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dc.authoridDoganlar, Zeynep Banu/0000-0002-1365-9897
dc.authoridZaim, Omer/0000-0002-3472-5611
dc.authoridOzcan, hafize/0000-0002-8031-6755
dc.authoridDoganlar, Oguzhan/0000-0003-2654-7269
dc.authorwosidZaim, Ömer/AAI-1470-2021
dc.authorwosidDoganlar, Zeynep Banu/B-4845-2008
dc.authorwosidDoğanlar, Oğuzhan/A-2315-2019
dc.authorwosidZaim, Omer/Q-7770-2019
dc.authorwosidOzcan, hafize/KJM-5364-2024
dc.contributor.authorZaim, Omer
dc.contributor.authorDoganlar, Oguzhan
dc.contributor.authorZreigh, Mohamed M.
dc.contributor.authorDoganlar, Zeynep Banu
dc.contributor.authorOzcan, Hafize
dc.date.accessioned2024-06-12T11:08:59Z
dc.date.available2024-06-12T11:08:59Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractNaringenin is a naturally occurring flavonoid and due to its broad spectrum of biological activities, including anticancer properties, has attracted scientific attention in recent years. To contribute to these studies, we synthesized some new (+/-)-naringenin cyclic aminoethyl derivatives, analyzed the cytotoxic and anti-proliferative properties of them via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, and mitochondrial apoptosis signaling response and gene expressions belong to caspase-3 depended apoptosis as biomarkers in both healthy and cancer cell lines. Our results suggest that some of our naringenin derivatives are potential anticancer agents with a selective death potential and targeting properties for mitochondrial apoptosis signaling against at least human cervix and breast cancer.en_US
dc.description.sponsorshipTrakya University Scientific Research Fund [TUBAP 2016/29]en_US
dc.description.sponsorshipThis research was financially supported by Trakya University Scientific Research Fund (Project No. TUBAP 2016/29).en_US
dc.identifier.doi10.1002/cbdv.201800016
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue7en_US
dc.identifier.pmid29766645en_US
dc.identifier.scopus2-s2.0-85049559344en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/cbdv.201800016
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22645
dc.identifier.volume15en_US
dc.identifier.wosWOS:000437830900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistry & Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNaringeninen_US
dc.subjectCytotoxic Activitiesen_US
dc.subjectAntiproliferative And Apoptotic Effectsen_US
dc.subjectHelaen_US
dc.subjectDU 145en_US
dc.subjectCell-Cycle Arresten_US
dc.subjectNaringenin Derivativesen_US
dc.subjectCarcinoma-Cellsen_US
dc.subjectA549 Cellsen_US
dc.subjectFlavonoidsen_US
dc.subjectChemotherapyen_US
dc.subjectAgentsen_US
dc.subjectAntioxidanten_US
dc.subjectDeathen_US
dc.subjectProliferationen_US
dc.titleSynthesis, Cancer-Selective Antiproliferative and Apoptotic Effects of Some (±)-Naringenin Cycloaminoethyl Derivativesen_US
dc.typeArticleen_US

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