Reversible cerebral vasoconstriction syndrome and recurrent headache triggered by antihistamine use

dc.contributor.authorGuler, Sibel
dc.contributor.authorUtku, Ufuk
dc.contributor.authorCelebi, Canan
dc.date.accessioned2024-06-12T10:51:58Z
dc.date.available2024-06-12T10:51:58Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractReversible cerebral vasoconstriction syndrome (RCVS), also known as Call-Fleming syndrome, is one of the rare causes of thunderclap headaches, which are most often seen in females aged 20-40 years and which can cause neurological deficits. The cause of RCVS is thought to be multifocal arterial constriction and dilatation caused by transient disregulation of cerebral vascular tonus. Presently described is case of 63-year-old female patient who presented with complaint of sudden onset of recurrent headaches located on the left side. Physical and neurological examinations were normal. Cranial magnetic resonance imaging (MRI) angiography examination showed vasoconstrictions in the distal, particularly in middle cerebral arteries and posterior cerebral arteries. Primary angitis of central nervous system (CNS), first considered in differential diagnosis, was excluded because no parenchymal lesion was seen in cranial MRI and no protein increase was observed in cerebrospinal fluid. Dexamethasone sodium phosphate 4 mg/mL (4 mg/day) and nimodipine 90 mg/day treatment was initiated. Nimodipine dose was gradually increased to 120 mg/day. Headache resolved significantly after discontinuation of antihistaminic agents. The most important feature of RCVS to be highlighted is that clinical signs are reversible, unlike subarachnoid hemorrhage or primary angitis of CNS, which have similar clinical presentations. Although clinical signs of RCVS usually resolve, it should be considered that permanent neurological deficits may occur.en_US
dc.identifier.doi10.5505/agri.2015.14632
dc.identifier.endpage89en_US
dc.identifier.issn1300-0012
dc.identifier.issue2en_US
dc.identifier.pmid28895985en_US
dc.identifier.scopus2-s2.0-85020474338en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage86en_US
dc.identifier.urihttps://doi.org/10.5505/agri.2015.14632
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18555
dc.identifier.volume29en_US
dc.identifier.wosWOS:000406222900007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherKare Publen_US
dc.relation.ispartofAgri-The Journal Of The Turkish Society Of Algologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntihistamine Useen_US
dc.subjectHeadacheen_US
dc.subjectReversible Cerebral Vasoconstriction Syndromeen_US
dc.subjectRecurrenten_US
dc.titleReversible cerebral vasoconstriction syndrome and recurrent headache triggered by antihistamine useen_US
dc.typeArticleen_US

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