Contrary effects of coenzyme Q10 and vitamin E after testicular ischemia/reperfusion in a rat model validated with glucose metabolism imaging

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dc.authoridArda, Ersan/0000-0002-5430-6561
dc.authoridAkdeniz, Esra/0000-0002-3549-5416
dc.authorwosidArda, Ersan/L-7357-2016
dc.authorwosidAkdeniz, Esra/AAC-6112-2020
dc.contributor.authorArda, Ersan
dc.contributor.authorYuksel, Ilkan
dc.contributor.authorAkdere, Hakan
dc.contributor.authorAkdeniz, Esra
dc.contributor.authorYalta, Tulin D.
dc.contributor.authorAktoz, Tevfik
dc.contributor.authorAltun, Gulay D.
dc.date.accessioned2024-06-12T11:07:06Z
dc.date.available2024-06-12T11:07:06Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: To evaluate the efficacy of antioxidants in cellular-level post-ischemia/reperfusion injury of the testis and to validate these effects with F-18-fluorodeoxyglucose positron emission tomography. Methods: Fifty-six adult male rats were randomly divided into seven groups-Group 1: sham; Group 2: ischemia/reperfusion only group; Group 3: ischemia was induced and vitamin E (100 mg/kg) was administered intraperitoneally 30 min before reperfusion; Group 4: vitamin E was given intraperitoneally without ischemia/reperfusion; Group 5: ischemia was induced and coenzyme Q10 (10 mg/body weight) was administered intraperitoneally 30 min before reperfusion; Group 6: coenzyme Q10 was administered intraperitoneally without ischemia/reperfusion; Group 7: ischemia was induced and coenzyme Q10 + vitamin E was administered intraperitoneally 30 min before reperfusion. After detorsion, fluorodeoxyglucose was applied to all groups according to the animals' weight and fluorodeoxyglucose positron emission tomography was performed after 1 h. In pursuit of imaging, orchiectomy was performed for histopathological and biochemical evaluations. Results: A significant effect of group on catalase, maximum standardized uptake value, and seminiferous tubule diameters (p < 0.005) was observed. According to this, combining ischemia/reperfusion with vitamin E increased the maximum standardized uptake value significantly higher than in all other groups; in addition, catalase was significantly higher than in Groups 4-6. Histopathological outcomes revealed that sham had significantly larger seminiferous tubule diameter than Groups 2-4. Also, ischemia/reperfusion was the only group which had significantly smaller seminiferous tubule diameters than Groups 6 and 7. Conclusion: In contrast to vitamin E, coenzyme Q10 provided remarkable regression of oxidative stress-induced enzymes and revealed consistent effects on histopathological outcomes, which were validated with fluorodeoxyglucose positron emission tomography imaging.en_US
dc.identifier.doi10.1177/0391560319882232
dc.identifier.endpage63en_US
dc.identifier.issn0391-5603
dc.identifier.issn1724-6075
dc.identifier.issue1en_US
dc.identifier.pmid31618144en_US
dc.identifier.startpage56en_US
dc.identifier.urihttps://doi.org/10.1177/0391560319882232
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21895
dc.identifier.volume88en_US
dc.identifier.wosWOS:000491448100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofUrologia Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia/Reperfusionen_US
dc.subjectTestisen_US
dc.subjectFluorodeoxyglucose Positron Emission Tomographyen_US
dc.subjectCoenzyme Q10en_US
dc.subjectVitamin Een_US
dc.subjectFdg-Pet/Cten_US
dc.subjectTorsionen_US
dc.subjectIschemiaen_US
dc.subjectInjuryen_US
dc.subjectTestesen_US
dc.subjectAntioxidantsen_US
dc.subjectAllopurinolen_US
dc.titleContrary effects of coenzyme Q10 and vitamin E after testicular ischemia/reperfusion in a rat model validated with glucose metabolism imagingen_US
dc.typeArticleen_US

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