Protective effects of quercetin on testicular torsion/detorsion-induced ischaemia-reperfusion injury in rats

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dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorAktoz, T.
dc.contributor.authorKanter, M.
dc.contributor.authorAktas, C.
dc.date.accessioned2024-06-12T11:00:26Z
dc.date.available2024-06-12T11:00:26Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractP>The aim of this study was to investigate the protective effect of quercetin (QE) on testicular torsion/detorsion-induced ischaemia-reperfusion (I/R) injury. A total of 24 male Wistar albino rats were divided into three groups: control, I/R and I/R treated with QE; each group contain eight animals. Testicular torsion was created by rotating the left testis 720 degrees in a clockwise direction. The ischaemia period was 5 h and orchiectomy was performed after 5 h of detorsion. QE (15 mg kg-1, i.p.) was administrated only once, 40 min prior to detorsion. Left orchiectomy was performed in all I/R groups. To date, no histopathological changes on testicular torsion/detorsion-induced I/R injury in rats by QE treatment have been reported. Spermatogenesis and mean seminiferous tubule diameter were significantly decreased in I/R groups were compared with the control group. Furthermore, QE treated animals showed an improved histological appearance in I/R group. Our data indicate a significant reduction in the activity of TUNEL, endothelial nitric oxide synthase and a rise in the expression of testosterone in testes tissue of I/R treated with QE therapy. We believe that further preclinical research into the utility of QE may indicate its usefulness as a potential treatment on testes injury after I/R in rats.en_US
dc.identifier.doi10.1111/j.1439-0272.2010.01044.x
dc.identifier.endpage383en_US
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue6en_US
dc.identifier.pmid21105888en_US
dc.identifier.scopus2-s2.0-78649546008en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage376en_US
dc.identifier.urihttps://doi.org/10.1111/j.1439-0272.2010.01044.x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20833
dc.identifier.volume42en_US
dc.identifier.wosWOS:000284615100005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEnosen_US
dc.subjectQuercetinen_US
dc.subjectTesticular Torsionen_US
dc.subjectTestosteroneen_US
dc.subjectTUNELen_US
dc.subjectCell-Specific Apoptosisen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectContralateral Testisen_US
dc.subjectDelayed Phaseen_US
dc.subjectGerm-Cellsen_US
dc.subjectTorsionen_US
dc.subjectTissueen_US
dc.subjectFlavonoidsen_US
dc.subjectCalpainen_US
dc.subjectSpermatogenesisen_US
dc.titleProtective effects of quercetin on testicular torsion/detorsion-induced ischaemia-reperfusion injury in ratsen_US
dc.typeArticleen_US

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