Solitary Fibrous Tumors of Chest: Another Look with the Oncologic Perspective

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dc.contributor.authorSaynak, Mert
dc.contributor.authorVeeramachaneni, Nirmal K.
dc.contributor.authorHubbs, Jessica L.
dc.contributor.authorOkumuş, Dilruba
dc.contributor.authorMarks, Lawrence B.
dc.date.accessioned2021-11-20T10:10:04Z
dc.date.available2021-11-20T10:10:04Z
dc.date.issued2017
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Anabilim Dalıen_US
dc.description.abstractSolitary fibrous tumors are mesenchymal lesions that arise at a variety of sites, most commonly the pleura. Most patients are asymptomatic at diagnosis, with lesions being detected incidentally. Nevertheless, some patients present due to symptoms from local tumor compression (eg. of the airways and pulmonary parenchyma). Furthermore, radiological methods are not always conclusive in making a diagnosis, and thus, pathological analysis is often required. In the past three decades, immunohistochemical techniques have provided a gold standard in solitary fibrous tumor diagnosis. The signature marker of solitary fibrous tumor is the presence of the NAB2-STAT6 fusion that can be reliably detected with a STAT6 antibody. While solitary fibrous tumors are most often benign, they can be malignant in 10-20% of the cases. Unfortunately, histological parameters are not always predictive of benign vs malignant solitary fibrous tumors. As solitary fibrous tumors are generally regarded as relatively chemoresistant tumors; treatment is often limited to localized treatment modalities. The optimal treatment of solitary fibrous tumors appears to be complete surgical resection for both primary and local recurrent disease. However, in cases of suboptimal resection, large disease burden, or advanced recurrence, a multidisciplinary approach may be preferable. Specifically, radiotherapy for inoperable local disease can provide palliation/shrinkage. Given their sometimes -unpredictable and often- protracted clinical course, long-term follow-up post-resection is recommended.en_US
dc.identifier.doi10.4274/balkanmedj.2017.0350en_US
dc.identifier.endpage199en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue3en_US
dc.identifier.pmid28443588en_US
dc.identifier.scopus2-s2.0-85019717985en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage188en_US
dc.identifier.trdizinid227548en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpJM05UUTRPQT09
dc.identifier.urihttps://hdl.handle.net/20.500.14551/5496
dc.identifier.volume34en_US
dc.identifier.wosWOS:000407614500002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240608_ID_Qen_US
dc.subjectCerrahien_US
dc.titleSolitary Fibrous Tumors of Chest: Another Look with the Oncologic Perspectiveen_US
dc.typeArticleen_US

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