Does dipyrone produce anxiolytic-like effects in mice?

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dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authoridUlugol, Ahmet/0000-0003-4643-1124;
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorTopuz, Ruhan Deniz
dc.contributor.authorGunduz, Ozgur
dc.contributor.authorDokmeci, Dikmen
dc.contributor.authorKaradag, Cetin Hakan
dc.contributor.authorUlugol, Ahmet
dc.date.accessioned2024-06-12T10:59:38Z
dc.date.available2024-06-12T10:59:38Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: Paracetamol has been shown to exert anxiolytic-like effects mediated by endocannabinoids via cannabinoid CB1 receptors. Dipyrone is an analgesic with similar effects to paracetamol rather than non-steroidal anti-inflammatory drugs. Involvement of central structures to its effects are long under debate, whereas recent findings suggesting contribution of cannabinoid CB1 receptors to its antinociceptive effect support this argument. Taken together, the purpose of this study was to investigate whether dipyrone possesses anxiolytic-like behavior; contribution of cannabinoid CB1 and CB2 receptors and TRPV1 receptors will be determined in case of observing any effect of dipyrone in anxiety tests. Material and Methods: Balb-c mice effects of dipyrone (150, 300, 600 mg/kg, i.p) were assessed in three-chamber social interaction, open-field, elevated plus-maze and rota rod tests. The cannabinoid CB1 antagonist AM251 (1 mg/kg i.p.), the CB2 antagonist SR 144528 (1 mg/kg i.p.) and the TRPV1 antagonist capsazepine (3 mg/kg i.p) were going to be administered before dipyrone injections if any effect of dipyrone occurs. Results: Dipyrone had no effect at any dose in behavioral tests (three-chamber social interaction, open-field, elevated plus-maze and rota rod tests). Therefore, dipyrone is not tested together with the cannabinoid CB1 and CB2 antagonists and the TRPV1 receptor antagonist. Conclusion: Unlike paracetamol, dipyrone did not possess anxiolytic-like effects in mice. Discrepancies in experimental models and methodologies may be the reason of our results.en_US
dc.identifier.doi10.17826/cumj.488406
dc.identifier.endpage874en_US
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue3en_US
dc.identifier.startpage866en_US
dc.identifier.trdizinid382262en_US
dc.identifier.urihttps://doi.org/10.17826/cumj.488406
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/382262
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20516
dc.identifier.volume44en_US
dc.identifier.wosWOS:000500930000022en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherCukurova Univ, Fac Medicineen_US
dc.relation.ispartofCukurova Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDipyroneen_US
dc.subjectAnxietyen_US
dc.subjectCannabinoiden_US
dc.subjectCannabinoid Cb1 Receptorsen_US
dc.subjectEndocannabinoid Systemen_US
dc.subjectSocial-Behavioren_US
dc.subjectPlus-Mazeen_US
dc.subjectInvolvementen_US
dc.subjectAnxietyen_US
dc.subjectPainen_US
dc.subjectAcetaminophenen_US
dc.subjectMechanismen_US
dc.subjectRaten_US
dc.titleDoes dipyrone produce anxiolytic-like effects in mice?en_US
dc.typeArticleen_US

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